MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting HDAC1 or eIF4E3 to enhance spindle defects and DNA...

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Autores principales:	Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton, Manjeet K. Rao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e6b817f247d44dd9e1ce5001fd43f4d
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spelling	oai:doaj.org-article:7e6b817f247d44dd9e1ce5001fd43f4d2021-12-02T16:49:21ZMiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma10.1038/s41467-018-06808-82041-1723https://doaj.org/article/7e6b817f247d44dd9e1ce5001fd43f4d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06808-8https://doaj.org/toc/2041-1723The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting HDAC1 or eIF4E3 to enhance spindle defects and DNA damage.Nourhan AbdelfattahSubapriya RajamanickamSubbarayalu PanneerdossSantosh TimilsinaPooja YadavBenjamin C. OnyeaguchaMichael GarciaRatna VadlamudiYidong ChenAndrew BrennerPeter HoughtonManjeet K. RaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nourhan Abdelfattah Subapriya Rajamanickam Subbarayalu Panneerdoss Santosh Timilsina Pooja Yadav Benjamin C. Onyeagucha Michael Garcia Ratna Vadlamudi Yidong Chen Andrew Brenner Peter Houghton Manjeet K. Rao MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
description	The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting HDAC1 or eIF4E3 to enhance spindle defects and DNA damage.
format	article
author	Nourhan Abdelfattah Subapriya Rajamanickam Subbarayalu Panneerdoss Santosh Timilsina Pooja Yadav Benjamin C. Onyeagucha Michael Garcia Ratna Vadlamudi Yidong Chen Andrew Brenner Peter Houghton Manjeet K. Rao
author_facet	Nourhan Abdelfattah Subapriya Rajamanickam Subbarayalu Panneerdoss Santosh Timilsina Pooja Yadav Benjamin C. Onyeagucha Michael Garcia Ratna Vadlamudi Yidong Chen Andrew Brenner Peter Houghton Manjeet K. Rao
author_sort	Nourhan Abdelfattah
title	MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
title_short	MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
title_full	MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
title_fullStr	MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
title_full_unstemmed	MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma
title_sort	mir-584-5p potentiates vincristine and radiation response by inducing spindle defects and dna damage in medulloblastoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7e6b817f247d44dd9e1ce5001fd43f4d
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MiR-584-5p potentiates vincristine and radiation response by inducing spindle defects and DNA damage in medulloblastoma

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