Polygenetic risk scores do not add predictive power to clinical models for response to anti-TNFα therapy in inflammatory bowel disease.

Polygenetic risk scores do not add predictive power to clinical models for response to anti-TNFα therapy in inflammatory bowel disease.

<h4>Background</h4>Anti-tumour necrosis factor alpha (TNFα) therapy is widely used in the management of Crohn's disease (CD) and ulcerative colitis (UC). However, up to a third of patients do not respond to induction therapy and another third of patients lose response over time. To...

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Autores principales: Naomi Karmi, Amber Bangma, Lieke M Spekhorst, Hendrik M van Dullemen, Marijn C Visschedijk, Gerard Dijkstra, Rinse K Weersma, Michiel D Voskuil, Eleonora A M Festen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/7e6c3516725d43519dd43909c7f20bd4
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