Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations

As a currently identified small non-coding RNAs (ncRNAs) category, the Piwi Interacting RNAs (piRNAs) are crucial mediators of cell biology. The human genome comprises over 30.000 piRNA genes. Although considered a new field in cancer research, the piRNA pathway is shown by the existing evidence as...

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Autores principales:	Pooneh Mokarram, Maryam Niknam, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Morvarid Siri, Sanaz Dastghaib, Hassan Brim, Hassan Ashktorab
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	non-coding rnas pirna piwi cancer Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/7e6d72fe81a8479c9c6f22785eb61dd1
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spelling	oai:doaj.org-article:7e6d72fe81a8479c9c6f22785eb61dd12021-11-04T15:51:54ZPiwi Interacting RNAs perspectives: A new avenues in future cancer investigations2165-59792165-598710.1080/21655979.2021.1997078https://doaj.org/article/7e6d72fe81a8479c9c6f22785eb61dd12021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1997078https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987As a currently identified small non-coding RNAs (ncRNAs) category, the Piwi Interacting RNAs (piRNAs) are crucial mediators of cell biology. The human genome comprises over 30.000 piRNA genes. Although considered a new field in cancer research, the piRNA pathway is shown by the existing evidence as an active pathway in a variety of different types of cancers with critical impacts on main aspects of cancer progression. Among the regulatory molecules that contribute to maintaining the dynamics of cancer cells, the P-element Induced WImpy testis (PIWI) proteins and piRNAs, as new players, have not been broadly studied so far. Therefore, the identification of cancer-related piRNAs and the assessment of target genes of piRNAs may lead to better cancer prevention and therapy strategies. This review article is aimed to highlight the role and function of piRNAs based on existing data. Understanding the role of piRNA in cancer may provide perspectives on their applications as particular biomarker signature in diagnosis in early stage, prognosis and therapeutic strategies.Pooneh MokarramMaryam NiknamMohammadamin SadeghdoustFarnaz AligolighasemabadiMorvarid SiriSanaz DastghaibHassan BrimHassan AshktorabTaylor & Francis Grouparticlenon-coding rnaspirnapiwicancerBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-coding rnas pirna piwi cancer Biotechnology TP248.13-248.65
spellingShingle	non-coding rnas pirna piwi cancer Biotechnology TP248.13-248.65 Pooneh Mokarram Maryam Niknam Mohammadamin Sadeghdoust Farnaz Aligolighasemabadi Morvarid Siri Sanaz Dastghaib Hassan Brim Hassan Ashktorab Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations
description	As a currently identified small non-coding RNAs (ncRNAs) category, the Piwi Interacting RNAs (piRNAs) are crucial mediators of cell biology. The human genome comprises over 30.000 piRNA genes. Although considered a new field in cancer research, the piRNA pathway is shown by the existing evidence as an active pathway in a variety of different types of cancers with critical impacts on main aspects of cancer progression. Among the regulatory molecules that contribute to maintaining the dynamics of cancer cells, the P-element Induced WImpy testis (PIWI) proteins and piRNAs, as new players, have not been broadly studied so far. Therefore, the identification of cancer-related piRNAs and the assessment of target genes of piRNAs may lead to better cancer prevention and therapy strategies. This review article is aimed to highlight the role and function of piRNAs based on existing data. Understanding the role of piRNA in cancer may provide perspectives on their applications as particular biomarker signature in diagnosis in early stage, prognosis and therapeutic strategies.
format	article
author	Pooneh Mokarram Maryam Niknam Mohammadamin Sadeghdoust Farnaz Aligolighasemabadi Morvarid Siri Sanaz Dastghaib Hassan Brim Hassan Ashktorab
author_facet	Pooneh Mokarram Maryam Niknam Mohammadamin Sadeghdoust Farnaz Aligolighasemabadi Morvarid Siri Sanaz Dastghaib Hassan Brim Hassan Ashktorab
author_sort	Pooneh Mokarram
title	Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations
title_short	Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations
title_full	Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations
title_fullStr	Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations
title_full_unstemmed	Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations
title_sort	piwi interacting rnas perspectives: a new avenues in future cancer investigations
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/7e6d72fe81a8479c9c6f22785eb61dd1
work_keys_str_mv	AT poonehmokarram piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT maryamniknam piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT mohammadaminsadeghdoust piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT farnazaligolighasemabadi piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT morvaridsiri piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT sanazdastghaib piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT hassanbrim piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations AT hassanashktorab piwiinteractingrnasperspectivesanewavenuesinfuturecancerinvestigations
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Piwi Interacting RNAs perspectives: A new avenues in future cancer investigations

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