Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model

Age-associated neurodegenerative diseases are known to have “impaired protein clearance” as one of the key features causing their onset and progression. Hence, homeostasis is the key to maintaining balance throughout the cellular system as an organism ages. Any imbalance in the protein clearance mac...

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Autores principales:	Anam Naseer, Snober Shabnam Mir, Krisztina Takacs-Vellai, Aamir Nazir
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sirtuins autophagy neurodegenerative diseases <i>C. elegans</i> Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7e71a1d9668e429ca36abf38a73e9e2b
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spelling	oai:doaj.org-article:7e71a1d9668e429ca36abf38a73e9e2b2021-11-25T17:54:57ZSirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model10.3390/ijms2222122631422-00671661-6596https://doaj.org/article/7e71a1d9668e429ca36abf38a73e9e2b2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12263https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Age-associated neurodegenerative diseases are known to have “impaired protein clearance” as one of the key features causing their onset and progression. Hence, homeostasis is the key to maintaining balance throughout the cellular system as an organism ages. Any imbalance in the protein clearance machinery is responsible for accumulation of unwanted proteins, leading to pathological consequences—manifesting in neurodegeneration and associated debilitating outcomes. Multiple processes are involved in regulating this phenomenon; however, failure to regulate the autophagic machinery is a critical process that hampers the protein clearing pathway, leading to neurodegeneration. Another important and widely known component that plays a role in modulating neurodegeneration is a class of proteins called sirtuins. These are class III histone deacetylases (HDACs) that are known to regulate various vital processes such as longevity, genomic stability, transcription and DNA repair. These enzymes are also known to modulate neurodegeneration in an autophagy-dependent manner. Considering its genetic relevance and ease of studying disease-related endpoints in neurodegeneration, the model system <i>Caenorhabditis elegans</i> has been successfully employed in deciphering various functional outcomes related to critical protein molecules, cell death pathways and their association with ageing. This review summarizes the vital role of sirtuins and autophagy in ageing and neurodegeneration, in particular highlighting the knowledge obtained using the <i>C. elegans</i> model system.Anam NaseerSnober Shabnam MirKrisztina Takacs-VellaiAamir NazirMDPI AGarticlesirtuinsautophagyneurodegenerative diseases<i>C. elegans</i>Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12263, p 12263 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sirtuins autophagy neurodegenerative diseases <i>C. elegans</i> Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sirtuins autophagy neurodegenerative diseases <i>C. elegans</i> Biology (General) QH301-705.5 Chemistry QD1-999 Anam Naseer Snober Shabnam Mir Krisztina Takacs-Vellai Aamir Nazir Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model
description	Age-associated neurodegenerative diseases are known to have “impaired protein clearance” as one of the key features causing their onset and progression. Hence, homeostasis is the key to maintaining balance throughout the cellular system as an organism ages. Any imbalance in the protein clearance machinery is responsible for accumulation of unwanted proteins, leading to pathological consequences—manifesting in neurodegeneration and associated debilitating outcomes. Multiple processes are involved in regulating this phenomenon; however, failure to regulate the autophagic machinery is a critical process that hampers the protein clearing pathway, leading to neurodegeneration. Another important and widely known component that plays a role in modulating neurodegeneration is a class of proteins called sirtuins. These are class III histone deacetylases (HDACs) that are known to regulate various vital processes such as longevity, genomic stability, transcription and DNA repair. These enzymes are also known to modulate neurodegeneration in an autophagy-dependent manner. Considering its genetic relevance and ease of studying disease-related endpoints in neurodegeneration, the model system <i>Caenorhabditis elegans</i> has been successfully employed in deciphering various functional outcomes related to critical protein molecules, cell death pathways and their association with ageing. This review summarizes the vital role of sirtuins and autophagy in ageing and neurodegeneration, in particular highlighting the knowledge obtained using the <i>C. elegans</i> model system.
format	article
author	Anam Naseer Snober Shabnam Mir Krisztina Takacs-Vellai Aamir Nazir
author_facet	Anam Naseer Snober Shabnam Mir Krisztina Takacs-Vellai Aamir Nazir
author_sort	Anam Naseer
title	Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model
title_short	Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model
title_full	Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model
title_fullStr	Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model
title_full_unstemmed	Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model
title_sort	sirtuins and autophagy in age-associated neurodegenerative diseases: lessons from the <i>c. elegans</i> model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7e71a1d9668e429ca36abf38a73e9e2b
work_keys_str_mv	AT anamnaseer sirtuinsandautophagyinageassociatedneurodegenerativediseaseslessonsfromtheicelegansimodel AT snobershabnammir sirtuinsandautophagyinageassociatedneurodegenerativediseaseslessonsfromtheicelegansimodel AT krisztinatakacsvellai sirtuinsandautophagyinageassociatedneurodegenerativediseaseslessonsfromtheicelegansimodel AT aamirnazir sirtuinsandautophagyinageassociatedneurodegenerativediseaseslessonsfromtheicelegansimodel
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Sirtuins and Autophagy in Age-Associated Neurodegenerative Diseases: Lessons from the <i>C. elegans</i> Model

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