Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p1...

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Autores principales:	Babu J. N. Reddy, Michelle Mattson, Caitlin L. Wynne, Omid Vadpey, Abdo Durra, Dail Chapman, Richard B. Vallee, Steven P. Gross
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e7d923186b3472a831167e71bd0f0c6
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spelling	oai:doaj.org-article:7e7d923186b3472a831167e71bd0f0c62021-12-02T16:49:26ZLoad-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro10.1038/ncomms122592041-1723https://doaj.org/article/7e7d923186b3472a831167e71bd0f0c62016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12259https://doaj.org/toc/2041-1723Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p150glued.Babu J. N. ReddyMichelle MattsonCaitlin L. WynneOmid VadpeyAbdo DurraDail ChapmanRichard B. ValleeSteven P. GrossNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Babu J. N. Reddy Michelle Mattson Caitlin L. Wynne Omid Vadpey Abdo Durra Dail Chapman Richard B. Vallee Steven P. Gross Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
description	Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on dynein regulators LIS1 and NudE/L, but not on p150glued.
format	article
author	Babu J. N. Reddy Michelle Mattson Caitlin L. Wynne Omid Vadpey Abdo Durra Dail Chapman Richard B. Vallee Steven P. Gross
author_facet	Babu J. N. Reddy Michelle Mattson Caitlin L. Wynne Omid Vadpey Abdo Durra Dail Chapman Richard B. Vallee Steven P. Gross
author_sort	Babu J. N. Reddy
title	Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
title_short	Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
title_full	Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
title_fullStr	Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
title_full_unstemmed	Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro
title_sort	load-induced enhancement of dynein force production by lis1–nude in vivo and in vitro
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7e7d923186b3472a831167e71bd0f0c6
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Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

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