Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity

Xi Chen,1 Chunlan Zhang,1 Wei Liu,2 Jingjing Zhang,1 Zhiguang Zhou1 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The...

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Autores principales:	Chen X, Zhang C, Liu W, Zhang J, Zhou Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	laparoscopic sleeve gastrectomy obesity thyroid function. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/7e7e5bf87f5244708845a090c0334d39
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spelling	oai:doaj.org-article:7e7e5bf87f5244708845a090c0334d392021-12-02T08:33:51ZLaparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity1178-7007https://doaj.org/article/7e7e5bf87f5244708845a090c0334d392020-10-01T00:00:00Zhttps://www.dovepress.com/laparoscopic-sleeve-gastrectomy-induced-decreases-in-ft3-and-tsh-are-r-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Xi Chen,1 Chunlan Zhang,1 Wei Liu,2 Jingjing Zhang,1 Zhiguang Zhou1 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China; 2Department of Metabolic Surgery, Department of Biliopancreatic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaCorrespondence: Jingjing ZhangNational Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Changsha 410011, Hunan, People’s Republic of ChinaEmail Doctorzhangjj@csu.edu.cnObjective: Laparoscopic sleeve gastrectomy (LSG) is one of the most effective therapies to treat obesity. However, whether LSG affects thyroid function remains elusive. Due to a lack of longitudinal research, we explored changes in thyroid function in euthyroid patients with obesity before and after LSG.Methods: In total, 109 participants (59 obese patients, 30 normal controls and 20 overweight subjects) were recruited from the Second Xiangya Hospital of Central South University (CSU). All patients underwent LSG, and metabolic indicators and free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were evaluated at baseline, 6 and 12 months postoperatively.Results: Compared to the normal control group, the concentrations of FT4 were decreased and TSH were increased in the obese group at baseline. Thyroid hormone levels in all participants were within the normal range during the 12 months after LSG. The concentrations of FT3 (4.83 ± 0.06 vs 5.03 ± 0.08, P = 0.023) and TSH (1.67 ± 0.11 vs 2.25 ± 0.18, P = 0.000) significantly decreased from baseline to 12 months postoperatively, while the concentrations of FT4 significantly increased (17.40 ± 0.52 vs 15.80 ± 0.32, P = 0.004). The decrease in fasting C-peptide (FCP) was related to the decline in FT3 and TSH during 12 months after LSG.Conclusion: Obesity is closely related to thyroid function. LSG promoted a significant decrease in FT3 and TSH and a significant increase in FT4 in euthyroid patients with obesity after LSG. The decline in FCP may be involved in the decrease in FT3 and TSH after LSG.Keywords: laparoscopic sleeve gastrectomy, obesity, thyroid functionChen XZhang CLiu WZhang JZhou ZDove Medical Pressarticlelaparoscopic sleeve gastrectomyobesitythyroid function.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4077-4084 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	laparoscopic sleeve gastrectomy obesity thyroid function. Specialties of internal medicine RC581-951
spellingShingle	laparoscopic sleeve gastrectomy obesity thyroid function. Specialties of internal medicine RC581-951 Chen X Zhang C Liu W Zhang J Zhou Z Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity
description	Xi Chen,1 Chunlan Zhang,1 Wei Liu,2 Jingjing Zhang,1 Zhiguang Zhou1 1National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, People’s Republic of China; 2Department of Metabolic Surgery, Department of Biliopancreatic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaCorrespondence: Jingjing ZhangNational Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Changsha 410011, Hunan, People’s Republic of ChinaEmail Doctorzhangjj@csu.edu.cnObjective: Laparoscopic sleeve gastrectomy (LSG) is one of the most effective therapies to treat obesity. However, whether LSG affects thyroid function remains elusive. Due to a lack of longitudinal research, we explored changes in thyroid function in euthyroid patients with obesity before and after LSG.Methods: In total, 109 participants (59 obese patients, 30 normal controls and 20 overweight subjects) were recruited from the Second Xiangya Hospital of Central South University (CSU). All patients underwent LSG, and metabolic indicators and free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH) were evaluated at baseline, 6 and 12 months postoperatively.Results: Compared to the normal control group, the concentrations of FT4 were decreased and TSH were increased in the obese group at baseline. Thyroid hormone levels in all participants were within the normal range during the 12 months after LSG. The concentrations of FT3 (4.83 ± 0.06 vs 5.03 ± 0.08, P = 0.023) and TSH (1.67 ± 0.11 vs 2.25 ± 0.18, P = 0.000) significantly decreased from baseline to 12 months postoperatively, while the concentrations of FT4 significantly increased (17.40 ± 0.52 vs 15.80 ± 0.32, P = 0.004). The decrease in fasting C-peptide (FCP) was related to the decline in FT3 and TSH during 12 months after LSG.Conclusion: Obesity is closely related to thyroid function. LSG promoted a significant decrease in FT3 and TSH and a significant increase in FT4 in euthyroid patients with obesity after LSG. The decline in FCP may be involved in the decrease in FT3 and TSH after LSG.Keywords: laparoscopic sleeve gastrectomy, obesity, thyroid function
format	article
author	Chen X Zhang C Liu W Zhang J Zhou Z
author_facet	Chen X Zhang C Liu W Zhang J Zhou Z
author_sort	Chen X
title	Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity
title_short	Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity
title_full	Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity
title_fullStr	Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity
title_full_unstemmed	Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity
title_sort	laparoscopic sleeve gastrectomy-induced decreases in ft3 and tsh are related to fasting c-peptide in euthyroid patients with obesity
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7e7e5bf87f5244708845a090c0334d39
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Laparoscopic Sleeve Gastrectomy-Induced Decreases in FT3 and TSH are Related to Fasting C-Peptide in Euthyroid Patients with Obesity

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