Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain

Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.

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Autores principales:	Louis-Etienne Lorenzo, Antoine G. Godin, Francesco Ferrini, Karine Bachand, Isabel Plasencia-Fernandez, Simon Labrecque, Alexandre A. Girard, Dominic Boudreau, Irenej Kianicka, Martin Gagnon, Nicolas Doyon, Alfredo Ribeiro-da-Silva, Yves De Koninck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7e8316d0d5b2495c8bdcf34c648c6da7
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spelling	oai:doaj.org-article:7e8316d0d5b2495c8bdcf34c648c6da72021-12-02T15:37:14ZEnhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain10.1038/s41467-019-14154-62041-1723https://doaj.org/article/7e8316d0d5b2495c8bdcf34c648c6da72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14154-6https://doaj.org/toc/2041-1723Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.Louis-Etienne LorenzoAntoine G. GodinFrancesco FerriniKarine BachandIsabel Plasencia-FernandezSimon LabrecqueAlexandre A. GirardDominic BoudreauIrenej KianickaMartin GagnonNicolas DoyonAlfredo Ribeiro-da-SilvaYves De KoninckNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Louis-Etienne Lorenzo Antoine G. Godin Francesco Ferrini Karine Bachand Isabel Plasencia-Fernandez Simon Labrecque Alexandre A. Girard Dominic Boudreau Irenej Kianicka Martin Gagnon Nicolas Doyon Alfredo Ribeiro-da-Silva Yves De Koninck Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
description	Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to KCC2 hypofunction.
format	article
author	Louis-Etienne Lorenzo Antoine G. Godin Francesco Ferrini Karine Bachand Isabel Plasencia-Fernandez Simon Labrecque Alexandre A. Girard Dominic Boudreau Irenej Kianicka Martin Gagnon Nicolas Doyon Alfredo Ribeiro-da-Silva Yves De Koninck
author_facet	Louis-Etienne Lorenzo Antoine G. Godin Francesco Ferrini Karine Bachand Isabel Plasencia-Fernandez Simon Labrecque Alexandre A. Girard Dominic Boudreau Irenej Kianicka Martin Gagnon Nicolas Doyon Alfredo Ribeiro-da-Silva Yves De Koninck
author_sort	Louis-Etienne Lorenzo
title	Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
title_short	Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
title_full	Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
title_fullStr	Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
title_full_unstemmed	Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
title_sort	enhancing neuronal chloride extrusion rescues α2/α3 gabaa-mediated analgesia in neuropathic pain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7e8316d0d5b2495c8bdcf34c648c6da7
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Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain

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