Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model

Curcumin is a polyphenolic compound present in turmeric with extensive uses in cooking foods and biomedical applications. However, due to its hydrophobic nature, it is poorly soluble in water and its bioavailability is very low on oral administration in organisms. In this study, we investigated the...

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Autores principales:	Mohammad Moniruzzaman, Hunhwan Kim, Haewon Shin, Hyunsoo Kim, Nayoung Kim, Sungyeon Chin, Adhimoolam Karthikeyan, Hyojick Choi, Gonsup Kim, Taesun Min
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanomedicine alternative of antibiotics growth hematology proteomics coliform bacteria Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7e84192c9bfb4375b52a987d225d22f4
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spelling	oai:doaj.org-article:7e84192c9bfb4375b52a987d225d22f42021-11-25T16:21:52ZEvaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model10.3390/antibiotics101112802079-6382https://doaj.org/article/7e84192c9bfb4375b52a987d225d22f42021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1280https://doaj.org/toc/2079-6382Curcumin is a polyphenolic compound present in turmeric with extensive uses in cooking foods and biomedical applications. However, due to its hydrophobic nature, it is poorly soluble in water and its bioavailability is very low on oral administration in organisms. In this study, we investigated the dietary curcumin nanospheres in a weaned piglet model based on the growth, serum biochemistry, proteomics, fecal coliform bacteria, and malodors in the feces of piglets. A total of 135 weaned piglets (Duroc × [Yorkshire × Landrace]) with an average initial body weight of 7.0 ± 1.0 kg (28 ± 1 days of age) were randomly distributed in 9 pens (15 pigs in each pen) fed the dietary curcumin nanospheres (CN) at 0 (control), 0.5 (T1), and 1.0 mL (T2) CN/kg of diet in triplicates for 21 days. At the end of the feeding trial, the results showed piglets fed 1.0 mL CN/kg diet had significantly higher growth performance and feed utilization than control diet (without CN). However, there were no significant differences in growth and feed utilization between piglets fed T1 and T2 diets. Serum glucose, gamma-glutamyl transferase, total bilirubin, amylase, and lipase contents were unaffected in piglets fed the experimental diets. Interestingly, piglets fed T1 and T2 diets showed significantly lower total cholesterol levels than control diet. In serum proteomics, a total of 103 differentially expressed proteins (DEPs) were identified in the piglets fed control, T1, and T2 diets, of which 14 DEPs were upregulated and 4 DEPs were downregulated. Fecal coliform bacteria and ammonia gas were significantly reduced in piglets fed T1 and T2 diets. Overall, the results indicated dietary supplementation of CN could enhance the growth, feed utilization, and immunity—and reduce fecal pathogenic bacteria as well as ammonia gas emissions—in weaned piglets.Mohammad MoniruzzamanHunhwan KimHaewon ShinHyunsoo KimNayoung KimSungyeon ChinAdhimoolam KarthikeyanHyojick ChoiGonsup KimTaesun MinMDPI AGarticlenanomedicinealternative of antibioticsgrowthhematologyproteomicscoliform bacteriaTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1280, p 1280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomedicine alternative of antibiotics growth hematology proteomics coliform bacteria Therapeutics. Pharmacology RM1-950
spellingShingle	nanomedicine alternative of antibiotics growth hematology proteomics coliform bacteria Therapeutics. Pharmacology RM1-950 Mohammad Moniruzzaman Hunhwan Kim Haewon Shin Hyunsoo Kim Nayoung Kim Sungyeon Chin Adhimoolam Karthikeyan Hyojick Choi Gonsup Kim Taesun Min Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
description	Curcumin is a polyphenolic compound present in turmeric with extensive uses in cooking foods and biomedical applications. However, due to its hydrophobic nature, it is poorly soluble in water and its bioavailability is very low on oral administration in organisms. In this study, we investigated the dietary curcumin nanospheres in a weaned piglet model based on the growth, serum biochemistry, proteomics, fecal coliform bacteria, and malodors in the feces of piglets. A total of 135 weaned piglets (Duroc × [Yorkshire × Landrace]) with an average initial body weight of 7.0 ± 1.0 kg (28 ± 1 days of age) were randomly distributed in 9 pens (15 pigs in each pen) fed the dietary curcumin nanospheres (CN) at 0 (control), 0.5 (T1), and 1.0 mL (T2) CN/kg of diet in triplicates for 21 days. At the end of the feeding trial, the results showed piglets fed 1.0 mL CN/kg diet had significantly higher growth performance and feed utilization than control diet (without CN). However, there were no significant differences in growth and feed utilization between piglets fed T1 and T2 diets. Serum glucose, gamma-glutamyl transferase, total bilirubin, amylase, and lipase contents were unaffected in piglets fed the experimental diets. Interestingly, piglets fed T1 and T2 diets showed significantly lower total cholesterol levels than control diet. In serum proteomics, a total of 103 differentially expressed proteins (DEPs) were identified in the piglets fed control, T1, and T2 diets, of which 14 DEPs were upregulated and 4 DEPs were downregulated. Fecal coliform bacteria and ammonia gas were significantly reduced in piglets fed T1 and T2 diets. Overall, the results indicated dietary supplementation of CN could enhance the growth, feed utilization, and immunity—and reduce fecal pathogenic bacteria as well as ammonia gas emissions—in weaned piglets.
format	article
author	Mohammad Moniruzzaman Hunhwan Kim Haewon Shin Hyunsoo Kim Nayoung Kim Sungyeon Chin Adhimoolam Karthikeyan Hyojick Choi Gonsup Kim Taesun Min
author_facet	Mohammad Moniruzzaman Hunhwan Kim Haewon Shin Hyunsoo Kim Nayoung Kim Sungyeon Chin Adhimoolam Karthikeyan Hyojick Choi Gonsup Kim Taesun Min
author_sort	Mohammad Moniruzzaman
title	Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
title_short	Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
title_full	Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
title_fullStr	Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
title_full_unstemmed	Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model
title_sort	evaluation of dietary curcumin nanospheres in a weaned piglet model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7e84192c9bfb4375b52a987d225d22f4
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Evaluation of Dietary Curcumin Nanospheres in a Weaned Piglet Model

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