Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation

Abstract Post-transplant thoracic air-leak syndrome (ALS) is rare but potentially life-threatening in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT). Nevertheless, papers on thoracic ALS are limited, and this complication remains largely unknown. We reviewed 423 adult...

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Autores principales:	Yao-Chung Liu, Yi-Hsin Chou, Po-Shen Ko, Hao-Yuan Wang, Nai-Wen Fan, Chia-Jen Liu, Liang-Tsai Hsiao, Sheng-Hsuan Chien, Tzeon-Jye Chiou, Jin-Hwang Liu, Jyh-Pyng Gau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e876f6d0bea4e1c973306fa49409aeb
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spelling	oai:doaj.org-article:7e876f6d0bea4e1c973306fa49409aeb2021-12-02T15:09:15ZRisk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation10.1038/s41598-019-48308-92045-2322https://doaj.org/article/7e876f6d0bea4e1c973306fa49409aeb2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48308-9https://doaj.org/toc/2045-2322Abstract Post-transplant thoracic air-leak syndrome (ALS) is rare but potentially life-threatening in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT). Nevertheless, papers on thoracic ALS are limited, and this complication remains largely unknown. We reviewed 423 adult patients undergoing allogeneic HSCT from 2003 to 2014. Risk factors, clinical features and survival for thoracic ALS were collected and analysed. Thirteen out of 423 patients (3.1%) developed post-transplant thoracic ALS, including two ALS patients in the early phase. The median age at HSCT was 33 years among 13 patients with thoracic ALS. Male patients were predominant (69%). The median onset time was 253 days (range: 40–2680) after HSCT. Multivariate analysis revealed that grade III–IV acute graft-versus-host disease (GVHD) (p = 0.017), extensive chronic GVHD (cGVHD) (p = 0.019) and prior history of pulmonary invasive fungal infection (p = 0.007) were significant risk factors for thoracic ALS. In patients with cGVHD, those with thoracic ALS had a significantly worse survival than those without thoracic ALS (p = 0.04). Currently, published data analysing and exploring post-transplant thoracic ALS are limited. Our study employed a large patient cohort and determined the risk factors and clinical features for post-transplant thoracic ALS.Yao-Chung LiuYi-Hsin ChouPo-Shen KoHao-Yuan WangNai-Wen FanChia-Jen LiuLiang-Tsai HsiaoSheng-Hsuan ChienTzeon-Jye ChiouJin-Hwang LiuJyh-Pyng GauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yao-Chung Liu Yi-Hsin Chou Po-Shen Ko Hao-Yuan Wang Nai-Wen Fan Chia-Jen Liu Liang-Tsai Hsiao Sheng-Hsuan Chien Tzeon-Jye Chiou Jin-Hwang Liu Jyh-Pyng Gau Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
description	Abstract Post-transplant thoracic air-leak syndrome (ALS) is rare but potentially life-threatening in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT). Nevertheless, papers on thoracic ALS are limited, and this complication remains largely unknown. We reviewed 423 adult patients undergoing allogeneic HSCT from 2003 to 2014. Risk factors, clinical features and survival for thoracic ALS were collected and analysed. Thirteen out of 423 patients (3.1%) developed post-transplant thoracic ALS, including two ALS patients in the early phase. The median age at HSCT was 33 years among 13 patients with thoracic ALS. Male patients were predominant (69%). The median onset time was 253 days (range: 40–2680) after HSCT. Multivariate analysis revealed that grade III–IV acute graft-versus-host disease (GVHD) (p = 0.017), extensive chronic GVHD (cGVHD) (p = 0.019) and prior history of pulmonary invasive fungal infection (p = 0.007) were significant risk factors for thoracic ALS. In patients with cGVHD, those with thoracic ALS had a significantly worse survival than those without thoracic ALS (p = 0.04). Currently, published data analysing and exploring post-transplant thoracic ALS are limited. Our study employed a large patient cohort and determined the risk factors and clinical features for post-transplant thoracic ALS.
format	article
author	Yao-Chung Liu Yi-Hsin Chou Po-Shen Ko Hao-Yuan Wang Nai-Wen Fan Chia-Jen Liu Liang-Tsai Hsiao Sheng-Hsuan Chien Tzeon-Jye Chiou Jin-Hwang Liu Jyh-Pyng Gau
author_facet	Yao-Chung Liu Yi-Hsin Chou Po-Shen Ko Hao-Yuan Wang Nai-Wen Fan Chia-Jen Liu Liang-Tsai Hsiao Sheng-Hsuan Chien Tzeon-Jye Chiou Jin-Hwang Liu Jyh-Pyng Gau
author_sort	Yao-Chung Liu
title	Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
title_short	Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
title_full	Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
title_fullStr	Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
title_full_unstemmed	Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
title_sort	risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7e876f6d0bea4e1c973306fa49409aeb
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Risk factors and clinical features for post-transplant thoracic air-leak syndrome in adult patients receiving allogeneic haematopoietic stem cell transplantation

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