Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.

<h4>Background</h4>Manipulations of the early environment are linked to long-lasting alterations of emotionality and social capabilities. Denial of rewarding mother-pup interactions in early life of rats could serve as model for child neglect. Negative consequences for social competence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anastasia Diamantopoulou, Androniki Raftogianni, Antonios Stamatakis, Filaretos Alikaridis, Melly S Oitzl, Fotini Stylianopoulou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e8b230ac98542cd8cecd8874fef149e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7e8b230ac98542cd8cecd8874fef149e
record_format	dspace
spelling	oai:doaj.org-article:7e8b230ac98542cd8cecd8874fef149e2021-11-18T07:24:14ZDenial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.1932-620310.1371/journal.pone.0033793https://doaj.org/article/7e8b230ac98542cd8cecd8874fef149e2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22479443/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Manipulations of the early environment are linked to long-lasting alterations of emotionality and social capabilities. Denial of rewarding mother-pup interactions in early life of rats could serve as model for child neglect. Negative consequences for social competence in later life, accompanied by changes in the serotonergic system would be expected. In contrast, rewarding mother-pup contact should promote adequate social abilities.<h4>Methodology/principal findings</h4>Male Wistar rats trained in a T-maze during postnatal days 10-13 under denial (DER) or permission (RER) of maternal contact were tested for play behavior in adolescence and for coping with defeat in adulthood. We estimated serotonin (5-HT) levels in the brain under basal conditions and following defeat, as well as serotonin receptor 1A (5-HT1A) and serotonin transporter (SERT) expression. DER rats exhibited increased aggressive-like play behavior in adolescence (i.e. increased nape attacks, p<0.0001) and selected a proactive coping style during defeat in adulthood (higher sum of proactive behaviors: number of attacks, flights, rearings and defensive upright posture; p = 0.011, p<0.05 vs RER, non-handled-NH). In adulthood, they had lower 5-HT levels in both the prefrontal cortex (p<0.05 vs RER) and the amygdala (p<0.05 vs NH), increased 5-HT levels following defeat (PFC p<0.0001) and decreased serotonin turnover (amygdala p = 0.008). The number of 5-HT1A immunopositive cells in the CA1 hippocampal area was increased (p<0.05 DER, vs RER, NH); SERT levels in the amygdala were elevated (p<0.05 vs RER, NH), but were lower in the prefrontal cortex (p<0.05 vs NH).<h4>Conclusions/significance</h4>Denial of expected maternal reward early in life negatively affects sociability and the serotonergic system in a complex manner. We propose that our animal model could contribute to the identification of the neurobiological correlates of early neglect effects on social behavior and coping with challenges, but also in parallel with the effects of a rewarding early-life environment.Anastasia DiamantopoulouAndroniki RaftogianniAntonios StamatakisFilaretos AlikaridisMelly S OitzlFotini StylianopoulouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33793 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anastasia Diamantopoulou Androniki Raftogianni Antonios Stamatakis Filaretos Alikaridis Melly S Oitzl Fotini Stylianopoulou Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
description	<h4>Background</h4>Manipulations of the early environment are linked to long-lasting alterations of emotionality and social capabilities. Denial of rewarding mother-pup interactions in early life of rats could serve as model for child neglect. Negative consequences for social competence in later life, accompanied by changes in the serotonergic system would be expected. In contrast, rewarding mother-pup contact should promote adequate social abilities.<h4>Methodology/principal findings</h4>Male Wistar rats trained in a T-maze during postnatal days 10-13 under denial (DER) or permission (RER) of maternal contact were tested for play behavior in adolescence and for coping with defeat in adulthood. We estimated serotonin (5-HT) levels in the brain under basal conditions and following defeat, as well as serotonin receptor 1A (5-HT1A) and serotonin transporter (SERT) expression. DER rats exhibited increased aggressive-like play behavior in adolescence (i.e. increased nape attacks, p<0.0001) and selected a proactive coping style during defeat in adulthood (higher sum of proactive behaviors: number of attacks, flights, rearings and defensive upright posture; p = 0.011, p<0.05 vs RER, non-handled-NH). In adulthood, they had lower 5-HT levels in both the prefrontal cortex (p<0.05 vs RER) and the amygdala (p<0.05 vs NH), increased 5-HT levels following defeat (PFC p<0.0001) and decreased serotonin turnover (amygdala p = 0.008). The number of 5-HT1A immunopositive cells in the CA1 hippocampal area was increased (p<0.05 DER, vs RER, NH); SERT levels in the amygdala were elevated (p<0.05 vs RER, NH), but were lower in the prefrontal cortex (p<0.05 vs NH).<h4>Conclusions/significance</h4>Denial of expected maternal reward early in life negatively affects sociability and the serotonergic system in a complex manner. We propose that our animal model could contribute to the identification of the neurobiological correlates of early neglect effects on social behavior and coping with challenges, but also in parallel with the effects of a rewarding early-life environment.
format	article
author	Anastasia Diamantopoulou Androniki Raftogianni Antonios Stamatakis Filaretos Alikaridis Melly S Oitzl Fotini Stylianopoulou
author_facet	Anastasia Diamantopoulou Androniki Raftogianni Antonios Stamatakis Filaretos Alikaridis Melly S Oitzl Fotini Stylianopoulou
author_sort	Anastasia Diamantopoulou
title	Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
title_short	Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
title_full	Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
title_fullStr	Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
title_full_unstemmed	Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
title_sort	denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7e8b230ac98542cd8cecd8874fef149e
work_keys_str_mv	AT anastasiadiamantopoulou denialofrewardintheneonateshapessociabilityandserotonergicactivityintheadultrat AT andronikiraftogianni denialofrewardintheneonateshapessociabilityandserotonergicactivityintheadultrat AT antoniosstamatakis denialofrewardintheneonateshapessociabilityandserotonergicactivityintheadultrat AT filaretosalikaridis denialofrewardintheneonateshapessociabilityandserotonergicactivityintheadultrat AT mellysoitzl denialofrewardintheneonateshapessociabilityandserotonergicactivityintheadultrat AT fotinistylianopoulou denialofrewardintheneonateshapessociabilityandserotonergicactivityintheadultrat
_version_	1718423484320710656

Denial of reward in the neonate shapes sociability and serotonergic activity in the adult rat.

Ejemplares similares