Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea

Abstract Low long-term heart rate variability (HRV), often observed in obstructive sleep apnea (OSA) patients, is a known risk factor for cardiovascular diseases. However, it is unclear how the type or duration of individual respiratory events modulate ultra-short-term HRV and beat-to-beat intervals...

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Autores principales:	Salla Hietakoste, Henri Korkalainen, Samu Kainulainen, Saara Sillanmäki, Sami Nikkonen, Sami Myllymaa, Brett Duce, Juha Töyräs, Timo Leppänen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7e8bad2d45434223bb7e2d4f91b8386c
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spelling	oai:doaj.org-article:7e8bad2d45434223bb7e2d4f91b8386c2021-12-02T16:18:03ZLonger apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea10.1038/s41598-020-77780-x2045-2322https://doaj.org/article/7e8bad2d45434223bb7e2d4f91b8386c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77780-xhttps://doaj.org/toc/2045-2322Abstract Low long-term heart rate variability (HRV), often observed in obstructive sleep apnea (OSA) patients, is a known risk factor for cardiovascular diseases. However, it is unclear how the type or duration of individual respiratory events modulate ultra-short-term HRV and beat-to-beat intervals (RR intervals). We aimed to examine the sex-specific changes in RR interval and ultra-short-term HRV during and after apneas and hypopneas of various durations. Electrocardiography signals, recorded as a part of clinical polysomnography, of 758 patients (396 men) with suspected OSA were analysed retrospectively. Average RR intervals and time-domain HRV parameters were determined during the respiratory event and the 15-s period immediately after the event. Parameters were analysed in three pooled sex-specific subgroups based on the respiratory event duration (10–20 s, 20–30 s, and > 30 s) separately for apneas and hypopneas. We observed that RR intervals shortened after the respiratory events and the magnitude of these changes increased in both sexes as the respiratory event duration increased. Furthermore, ultra-short-term HRV generally increased as the respiratory event duration increased. Apneas caused higher ultra-short-term HRV and a stronger decrease in RR interval compared to hypopneas. In conclusion, the respiratory event type and duration modulate ultra-short-term HRV and RR intervals. Considering HRV and the respiratory event characteristics in the diagnosis of OSA could be useful when assessing the cardiac consequences of OSA in a more detailed manner.Salla HietakosteHenri KorkalainenSamu KainulainenSaara SillanmäkiSami NikkonenSami MyllymaaBrett DuceJuha TöyräsTimo LeppänenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Salla Hietakoste Henri Korkalainen Samu Kainulainen Saara Sillanmäki Sami Nikkonen Sami Myllymaa Brett Duce Juha Töyräs Timo Leppänen Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea
description	Abstract Low long-term heart rate variability (HRV), often observed in obstructive sleep apnea (OSA) patients, is a known risk factor for cardiovascular diseases. However, it is unclear how the type or duration of individual respiratory events modulate ultra-short-term HRV and beat-to-beat intervals (RR intervals). We aimed to examine the sex-specific changes in RR interval and ultra-short-term HRV during and after apneas and hypopneas of various durations. Electrocardiography signals, recorded as a part of clinical polysomnography, of 758 patients (396 men) with suspected OSA were analysed retrospectively. Average RR intervals and time-domain HRV parameters were determined during the respiratory event and the 15-s period immediately after the event. Parameters were analysed in three pooled sex-specific subgroups based on the respiratory event duration (10–20 s, 20–30 s, and > 30 s) separately for apneas and hypopneas. We observed that RR intervals shortened after the respiratory events and the magnitude of these changes increased in both sexes as the respiratory event duration increased. Furthermore, ultra-short-term HRV generally increased as the respiratory event duration increased. Apneas caused higher ultra-short-term HRV and a stronger decrease in RR interval compared to hypopneas. In conclusion, the respiratory event type and duration modulate ultra-short-term HRV and RR intervals. Considering HRV and the respiratory event characteristics in the diagnosis of OSA could be useful when assessing the cardiac consequences of OSA in a more detailed manner.
format	article
author	Salla Hietakoste Henri Korkalainen Samu Kainulainen Saara Sillanmäki Sami Nikkonen Sami Myllymaa Brett Duce Juha Töyräs Timo Leppänen
author_facet	Salla Hietakoste Henri Korkalainen Samu Kainulainen Saara Sillanmäki Sami Nikkonen Sami Myllymaa Brett Duce Juha Töyräs Timo Leppänen
author_sort	Salla Hietakoste
title	Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea
title_short	Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea
title_full	Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea
title_fullStr	Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea
title_full_unstemmed	Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea
title_sort	longer apneas and hypopneas are associated with greater ultra-short-term hrv in obstructive sleep apnea
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7e8bad2d45434223bb7e2d4f91b8386c
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Longer apneas and hypopneas are associated with greater ultra-short-term HRV in obstructive sleep apnea

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