Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients
Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogene, and proliferative activity measured with ki-67...
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2021
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oai:doaj.org-article:7e8e35352d69413ab774855b594b5c0e2021-11-25T18:02:36ZImmunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients10.3390/jcm102254162077-0383https://doaj.org/article/7e8e35352d69413ab774855b594b5c0e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5416https://doaj.org/toc/2077-0383Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogene, and proliferative activity measured with ki-67 provide important information on the biological features of BC and guide treatment choices. However, a biomarker that allows a more accurate prognostic stratification is still lacking. Thymidine kinase-1 (TK1), a ubiquitous enzyme involved in the pyrimidine nucleotide recovery pathway, is a cell-proliferation marker with potential prognostic and predictive impacts in BC. Eighty (80) cases of invasive BC with a long-term follow-up were retrospectively selected, and clinicopathological data were collected for each patient. TK1 tissue expression was evaluated immunohistochemically. Data suggested that TK1 expression levels are positively correlated with ER and PgR expression, and negatively correlated with HER2 status and the impact on patients’ distant recurrence-free survival (DRFS): in detail, among patients undergoing adjuvant chemotherapy, lower TK1 levels are correlated with better DRFS. Therefore, these results contribute to furthering the knowledge of TK1, suggesting a possible and important role of this enzyme as a biomarker in the stratification of BC patients.Giuseppe Nicolò FanelliRosa ScarpittaPaola CinacchiBeatrice FuochiAnna Szumera-CiećkiewiczKatia De IesoPaola FerrariAndrea FontanaMario MiccoliAntonio Giuseppe NaccaratoCristian ScatenaMDPI AGarticlebreast cancerthymidine kinase-1prognosisdistant recurrence-free survivaloverall survivalchemotherapyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5416, p 5416 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
breast cancer thymidine kinase-1 prognosis distant recurrence-free survival overall survival chemotherapy Medicine R |
| spellingShingle |
breast cancer thymidine kinase-1 prognosis distant recurrence-free survival overall survival chemotherapy Medicine R Giuseppe Nicolò Fanelli Rosa Scarpitta Paola Cinacchi Beatrice Fuochi Anna Szumera-Ciećkiewicz Katia De Ieso Paola Ferrari Andrea Fontana Mario Miccoli Antonio Giuseppe Naccarato Cristian Scatena Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients |
| description |
Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogene, and proliferative activity measured with ki-67 provide important information on the biological features of BC and guide treatment choices. However, a biomarker that allows a more accurate prognostic stratification is still lacking. Thymidine kinase-1 (TK1), a ubiquitous enzyme involved in the pyrimidine nucleotide recovery pathway, is a cell-proliferation marker with potential prognostic and predictive impacts in BC. Eighty (80) cases of invasive BC with a long-term follow-up were retrospectively selected, and clinicopathological data were collected for each patient. TK1 tissue expression was evaluated immunohistochemically. Data suggested that TK1 expression levels are positively correlated with ER and PgR expression, and negatively correlated with HER2 status and the impact on patients’ distant recurrence-free survival (DRFS): in detail, among patients undergoing adjuvant chemotherapy, lower TK1 levels are correlated with better DRFS. Therefore, these results contribute to furthering the knowledge of TK1, suggesting a possible and important role of this enzyme as a biomarker in the stratification of BC patients. |
| format |
article |
| author |
Giuseppe Nicolò Fanelli Rosa Scarpitta Paola Cinacchi Beatrice Fuochi Anna Szumera-Ciećkiewicz Katia De Ieso Paola Ferrari Andrea Fontana Mario Miccoli Antonio Giuseppe Naccarato Cristian Scatena |
| author_facet |
Giuseppe Nicolò Fanelli Rosa Scarpitta Paola Cinacchi Beatrice Fuochi Anna Szumera-Ciećkiewicz Katia De Ieso Paola Ferrari Andrea Fontana Mario Miccoli Antonio Giuseppe Naccarato Cristian Scatena |
| author_sort |
Giuseppe Nicolò Fanelli |
| title |
Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients |
| title_short |
Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients |
| title_full |
Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients |
| title_fullStr |
Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients |
| title_full_unstemmed |
Immunohistochemistry for Thymidine Kinase-1 (TK1): A Potential Tool for the Prognostic Stratification of Breast Cancer Patients |
| title_sort |
immunohistochemistry for thymidine kinase-1 (tk1): a potential tool for the prognostic stratification of breast cancer patients |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/7e8e35352d69413ab774855b594b5c0e |
| work_keys_str_mv |
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