Fuchs endothelial corneal dystrophy: current perspectives

Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease incl...

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Autores principales:	Vedana G, Villarreal Jr G, Jun AS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Fuchs endothelial corneal dystrophy (FECD) corneal endothelial cell corneal transplantation Descemet stripping automated endothelial keratoplasty (DSAEK) Descemet membrane endothelial keratoplasty (DMEK) endothelial keratoplasty. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7e92013fd46e432992676b35f0f7a83d
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spelling	oai:doaj.org-article:7e92013fd46e432992676b35f0f7a83d2021-12-02T06:31:07ZFuchs endothelial corneal dystrophy: current perspectives1177-5483https://doaj.org/article/7e92013fd46e432992676b35f0f7a83d2016-02-01T00:00:00Zhttps://www.dovepress.com/fuchs-endothelial-corneal-dystrophy-current-perspectives-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet’s membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD’s clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments. Keywords: Fuchs endothelial corneal dystrophy, corneal endothelial cell, corneal transplantation, Descemet’s stripping automated endothelial keratoplasty, Descemet’s membrane endothelial keratoplasty, endothelial keratoplastyVedana GVillarreal Jr GJun ASDove Medical PressarticleFuchs endothelial corneal dystrophy (FECD)corneal endothelial cellcorneal transplantationDescemet stripping automated endothelial keratoplasty (DSAEK)Descemet membrane endothelial keratoplasty (DMEK)endothelial keratoplasty.OphthalmologyRE1-994ENClinical Ophthalmology, Vol 2016, Iss Issue 1, Pp 321-330 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fuchs endothelial corneal dystrophy (FECD) corneal endothelial cell corneal transplantation Descemet stripping automated endothelial keratoplasty (DSAEK) Descemet membrane endothelial keratoplasty (DMEK) endothelial keratoplasty. Ophthalmology RE1-994
spellingShingle	Fuchs endothelial corneal dystrophy (FECD) corneal endothelial cell corneal transplantation Descemet stripping automated endothelial keratoplasty (DSAEK) Descemet membrane endothelial keratoplasty (DMEK) endothelial keratoplasty. Ophthalmology RE1-994 Vedana G Villarreal Jr G Jun AS Fuchs endothelial corneal dystrophy: current perspectives
description	Gustavo Vedana, Guadalupe Villarreal Jr, Albert S Jun Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA Abstract: Fuchs endothelial corneal dystrophy (FECD) is the most common corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet’s membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD’s clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments. Keywords: Fuchs endothelial corneal dystrophy, corneal endothelial cell, corneal transplantation, Descemet’s stripping automated endothelial keratoplasty, Descemet’s membrane endothelial keratoplasty, endothelial keratoplasty
format	article
author	Vedana G Villarreal Jr G Jun AS
author_facet	Vedana G Villarreal Jr G Jun AS
author_sort	Vedana G
title	Fuchs endothelial corneal dystrophy: current perspectives
title_short	Fuchs endothelial corneal dystrophy: current perspectives
title_full	Fuchs endothelial corneal dystrophy: current perspectives
title_fullStr	Fuchs endothelial corneal dystrophy: current perspectives
title_full_unstemmed	Fuchs endothelial corneal dystrophy: current perspectives
title_sort	fuchs endothelial corneal dystrophy: current perspectives
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7e92013fd46e432992676b35f0f7a83d
work_keys_str_mv	AT vedanag fuchsendothelialcornealdystrophycurrentperspectives AT villarrealjrg fuchsendothelialcornealdystrophycurrentperspectives AT junas fuchsendothelialcornealdystrophycurrentperspectives
_version_	1718399878877413376

Fuchs endothelial corneal dystrophy: current perspectives

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