Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and...

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Autores principales:	Iben Lundgaard, Aryna Luzhynskaya, John H Stockley, Zhen Wang, Kimberley A Evans, Matthew Swire, Katrin Volbracht, Hélène O B Gautier, Robin J M Franklin, Charles Ffrench-Constant, David Attwell, Ragnhildur T Káradóttir
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7e96a805c1684d3badfd87ae39c156c2
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spelling	oai:doaj.org-article:7e96a805c1684d3badfd87ae39c156c22021-11-18T05:37:40ZNeuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.1544-91731545-788510.1371/journal.pbio.1001743https://doaj.org/article/7e96a805c1684d3badfd87ae39c156c22013-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391468/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and glutamate release and another that depends on neuronal action potentials releasing glutamate to activate NMDA receptors on oligodendrocyte lineage cells. Neuregulin switches oligodendrocytes from the activity-independent to the activity-dependent mode of myelination by increasing NMDA receptor currents in oligodendrocyte lineage cells 6-fold. With neuregulin present myelination is accelerated and increased, and NMDA receptor block reduces myelination to far below its level without neuregulin. Thus, a neuregulin-controlled switch enhances the myelination of active axons. In vivo, we demonstrate that remyelination after white matter damage is NMDA receptor-dependent. These data resolve controversies over the signalling regulating myelination and suggest novel roles for neuregulin in schizophrenia and in remyelination after white matter damage.Iben LundgaardAryna LuzhynskayaJohn H StockleyZhen WangKimberley A EvansMatthew SwireKatrin VolbrachtHélène O B GautierRobin J M FranklinCharles Ffrench-ConstantDavid AttwellRagnhildur T KáradóttirPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 11, Iss 12, p e1001743 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Iben Lundgaard Aryna Luzhynskaya John H Stockley Zhen Wang Kimberley A Evans Matthew Swire Katrin Volbracht Hélène O B Gautier Robin J M Franklin Charles Ffrench-Constant David Attwell Ragnhildur T Káradóttir Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
description	Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and glutamate release and another that depends on neuronal action potentials releasing glutamate to activate NMDA receptors on oligodendrocyte lineage cells. Neuregulin switches oligodendrocytes from the activity-independent to the activity-dependent mode of myelination by increasing NMDA receptor currents in oligodendrocyte lineage cells 6-fold. With neuregulin present myelination is accelerated and increased, and NMDA receptor block reduces myelination to far below its level without neuregulin. Thus, a neuregulin-controlled switch enhances the myelination of active axons. In vivo, we demonstrate that remyelination after white matter damage is NMDA receptor-dependent. These data resolve controversies over the signalling regulating myelination and suggest novel roles for neuregulin in schizophrenia and in remyelination after white matter damage.
format	article
author	Iben Lundgaard Aryna Luzhynskaya John H Stockley Zhen Wang Kimberley A Evans Matthew Swire Katrin Volbracht Hélène O B Gautier Robin J M Franklin Charles Ffrench-Constant David Attwell Ragnhildur T Káradóttir
author_facet	Iben Lundgaard Aryna Luzhynskaya John H Stockley Zhen Wang Kimberley A Evans Matthew Swire Katrin Volbracht Hélène O B Gautier Robin J M Franklin Charles Ffrench-Constant David Attwell Ragnhildur T Káradóttir
author_sort	Iben Lundgaard
title	Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
title_short	Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
title_full	Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
title_fullStr	Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
title_full_unstemmed	Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
title_sort	neuregulin and bdnf induce a switch to nmda receptor-dependent myelination by oligodendrocytes.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7e96a805c1684d3badfd87ae39c156c2
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Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.

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