Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens

ABSTRACT Recent data in humans indicate that immunosuppression is correlated with shifts in the intestinal microbiota. However, the relationship between immunosuppression and intestinal microbiota has not been studied in chickens. Thus, we investigated the correlations between immune cells and intes...

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Autores principales:	Dany Mesa, Breno C. B. Beirão, Eduardo Balsanelli, Luiz Sesti, Luiz F. Caron, Leonardo M. Cruz, Emanuel M. Souza
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	broiler immunosuppression Faecalibacterium cloacal bursa chicken IgA Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7e9d4c66e085420699a03121c32bfcc2
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spelling	oai:doaj.org-article:7e9d4c66e085420699a03121c32bfcc22021-12-02T18:44:37ZCyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens10.1128/mSystems.00080-202379-5077https://doaj.org/article/7e9d4c66e085420699a03121c32bfcc22020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00080-20https://doaj.org/toc/2379-5077ABSTRACT Recent data in humans indicate that immunosuppression is correlated with shifts in the intestinal microbiota. However, the relationship between immunosuppression and intestinal microbiota has not been studied in chickens. Thus, we investigated the correlations between immune cells and intestinal microbiota by massive parallel sequencing of the 16S rRNA bacterial gene in chickens immunosuppressed with cyclophosphamide. The results showed correlations between peripheral immune cells and intestinal microbiota. Surprisingly, an increase in the abundance of intestinal Lactobacillus in the immunosuppressed chickens was observed. These birds also had low intestinal IgA antibody levels among other alterations in the microbiota. These shifts indicate a role of the immunity system in controlling the microbiota of birds. IMPORTANCE Poultry production is a very intensive industry. Due to the substantial number of animals being raised by any one producer, even small variations in productivity lead to important economical outcomes. The intestinal microbiota of birds is under intense scrutiny by the immune system. Therefore, it is a factor that can influence the states of health and disease of the host. The body of knowledge on the interactions between these systems is gradually bringing practical guidance for poultry production.Dany MesaBreno C. B. BeirãoEduardo BalsanelliLuiz SestiLuiz F. CaronLeonardo M. CruzEmanuel M. SouzaAmerican Society for MicrobiologyarticlebroilerimmunosuppressionFaecalibacteriumcloacal bursachickenIgAMicrobiologyQR1-502ENmSystems, Vol 5, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	broiler immunosuppression Faecalibacterium cloacal bursa chicken IgA Microbiology QR1-502
spellingShingle	broiler immunosuppression Faecalibacterium cloacal bursa chicken IgA Microbiology QR1-502 Dany Mesa Breno C. B. Beirão Eduardo Balsanelli Luiz Sesti Luiz F. Caron Leonardo M. Cruz Emanuel M. Souza Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens
description	ABSTRACT Recent data in humans indicate that immunosuppression is correlated with shifts in the intestinal microbiota. However, the relationship between immunosuppression and intestinal microbiota has not been studied in chickens. Thus, we investigated the correlations between immune cells and intestinal microbiota by massive parallel sequencing of the 16S rRNA bacterial gene in chickens immunosuppressed with cyclophosphamide. The results showed correlations between peripheral immune cells and intestinal microbiota. Surprisingly, an increase in the abundance of intestinal Lactobacillus in the immunosuppressed chickens was observed. These birds also had low intestinal IgA antibody levels among other alterations in the microbiota. These shifts indicate a role of the immunity system in controlling the microbiota of birds. IMPORTANCE Poultry production is a very intensive industry. Due to the substantial number of animals being raised by any one producer, even small variations in productivity lead to important economical outcomes. The intestinal microbiota of birds is under intense scrutiny by the immune system. Therefore, it is a factor that can influence the states of health and disease of the host. The body of knowledge on the interactions between these systems is gradually bringing practical guidance for poultry production.
format	article
author	Dany Mesa Breno C. B. Beirão Eduardo Balsanelli Luiz Sesti Luiz F. Caron Leonardo M. Cruz Emanuel M. Souza
author_facet	Dany Mesa Breno C. B. Beirão Eduardo Balsanelli Luiz Sesti Luiz F. Caron Leonardo M. Cruz Emanuel M. Souza
author_sort	Dany Mesa
title	Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens
title_short	Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens
title_full	Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens
title_fullStr	Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens
title_full_unstemmed	Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens
title_sort	cyclophosphamide increases <italic toggle="yes">lactobacillus</italic> in the intestinal microbiota in chickens
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/7e9d4c66e085420699a03121c32bfcc2
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Cyclophosphamide Increases <italic toggle="yes">Lactobacillus</italic> in the Intestinal Microbiota in Chickens

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