Contradictory roles of lipid metabolism in immune response within the tumor microenvironment

Abstract Complex interactions between the immune system and tumor cells exist throughout the initiation and development of cancer. Although the immune system eliminates malignantly transformed cells in the early stage, surviving tumor cells evade host immune defense through various methods and even...

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Autores principales:	Weina Yu, Qingyang Lei, Li Yang, Guohui Qin, Shasha Liu, Dan Wang, Yu Ping, Yi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lipid metabolism Malignant tumor Immune response Tumor microenvironment Immunotherapy Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7e9d75f5472d4906afe486a7429609bc
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spelling	oai:doaj.org-article:7e9d75f5472d4906afe486a7429609bc2021-11-07T12:03:01ZContradictory roles of lipid metabolism in immune response within the tumor microenvironment10.1186/s13045-021-01200-41756-8722https://doaj.org/article/7e9d75f5472d4906afe486a7429609bc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13045-021-01200-4https://doaj.org/toc/1756-8722Abstract Complex interactions between the immune system and tumor cells exist throughout the initiation and development of cancer. Although the immune system eliminates malignantly transformed cells in the early stage, surviving tumor cells evade host immune defense through various methods and even reprogram the anti-tumor immune response to a pro-tumor phenotype to obtain unlimited growth and metastasis. The high proliferation rate of tumor cells increases the demand for local nutrients and oxygen. Poorly organized vessels can barely satisfy this requirement, which results in an acidic, hypoxic, and glucose-deficient tumor microenvironment. As a result, lipids in the tumor microenvironment are activated and utilized as a primary source of energy and critical regulators in both tumor cells and related immune cells. However, the exact role of lipid metabolism reprogramming in tumor immune response remains unclear. A comprehensive understanding of lipid metabolism dysfunction in the tumor microenvironment and its dual effects on the immune response is critical for mapping the detailed landscape of tumor immunology and developing specific treatments for cancer patients. In this review, we have focused on the dysregulation of lipid metabolism in the tumor microenvironment and have discussed its contradictory roles in the tumor immune response. In addition, we have summarized the current therapeutic strategies targeting lipid metabolism in tumor immunotherapy. This review provides a comprehensive summary of lipid metabolism in the tumor immune response.Weina YuQingyang LeiLi YangGuohui QinShasha LiuDan WangYu PingYi ZhangBMCarticleLipid metabolismMalignant tumorImmune responseTumor microenvironmentImmunotherapyDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lipid metabolism Malignant tumor Immune response Tumor microenvironment Immunotherapy Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Lipid metabolism Malignant tumor Immune response Tumor microenvironment Immunotherapy Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Weina Yu Qingyang Lei Li Yang Guohui Qin Shasha Liu Dan Wang Yu Ping Yi Zhang Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
description	Abstract Complex interactions between the immune system and tumor cells exist throughout the initiation and development of cancer. Although the immune system eliminates malignantly transformed cells in the early stage, surviving tumor cells evade host immune defense through various methods and even reprogram the anti-tumor immune response to a pro-tumor phenotype to obtain unlimited growth and metastasis. The high proliferation rate of tumor cells increases the demand for local nutrients and oxygen. Poorly organized vessels can barely satisfy this requirement, which results in an acidic, hypoxic, and glucose-deficient tumor microenvironment. As a result, lipids in the tumor microenvironment are activated and utilized as a primary source of energy and critical regulators in both tumor cells and related immune cells. However, the exact role of lipid metabolism reprogramming in tumor immune response remains unclear. A comprehensive understanding of lipid metabolism dysfunction in the tumor microenvironment and its dual effects on the immune response is critical for mapping the detailed landscape of tumor immunology and developing specific treatments for cancer patients. In this review, we have focused on the dysregulation of lipid metabolism in the tumor microenvironment and have discussed its contradictory roles in the tumor immune response. In addition, we have summarized the current therapeutic strategies targeting lipid metabolism in tumor immunotherapy. This review provides a comprehensive summary of lipid metabolism in the tumor immune response.
format	article
author	Weina Yu Qingyang Lei Li Yang Guohui Qin Shasha Liu Dan Wang Yu Ping Yi Zhang
author_facet	Weina Yu Qingyang Lei Li Yang Guohui Qin Shasha Liu Dan Wang Yu Ping Yi Zhang
author_sort	Weina Yu
title	Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
title_short	Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
title_full	Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
title_fullStr	Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
title_full_unstemmed	Contradictory roles of lipid metabolism in immune response within the tumor microenvironment
title_sort	contradictory roles of lipid metabolism in immune response within the tumor microenvironment
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7e9d75f5472d4906afe486a7429609bc
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Contradictory roles of lipid metabolism in immune response within the tumor microenvironment

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