BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

Cancer mutational signatures have been associated with defects in genome maintenance pathways. Here the authors, by using a worm germline mutagenesis model defective of human orthologue BRCA-1, identify polymerase theta-mediated end-joining (TMEJ) as causing the BRCAness mutational signature.

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Autores principales: J. A. Kamp, R. van Schendel, I. W. Dilweg, M. Tijsterman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7e9ffb55af7f4b2f9a5cfebaf60ef6ca
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spelling oai:doaj.org-article:7e9ffb55af7f4b2f9a5cfebaf60ef6ca2021-12-02T17:01:15ZBRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining10.1038/s41467-020-17455-32041-1723https://doaj.org/article/7e9ffb55af7f4b2f9a5cfebaf60ef6ca2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17455-3https://doaj.org/toc/2041-1723Cancer mutational signatures have been associated with defects in genome maintenance pathways. Here the authors, by using a worm germline mutagenesis model defective of human orthologue BRCA-1, identify polymerase theta-mediated end-joining (TMEJ) as causing the BRCAness mutational signature.J. A. KampR. van SchendelI. W. DilwegM. TijstermanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
J. A. Kamp
R. van Schendel
I. W. Dilweg
M. Tijsterman
BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
description Cancer mutational signatures have been associated with defects in genome maintenance pathways. Here the authors, by using a worm germline mutagenesis model defective of human orthologue BRCA-1, identify polymerase theta-mediated end-joining (TMEJ) as causing the BRCAness mutational signature.
format article
author J. A. Kamp
R. van Schendel
I. W. Dilweg
M. Tijsterman
author_facet J. A. Kamp
R. van Schendel
I. W. Dilweg
M. Tijsterman
author_sort J. A. Kamp
title BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
title_short BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
title_full BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
title_fullStr BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
title_full_unstemmed BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining
title_sort brca1-associated structural variations are a consequence of polymerase theta-mediated end-joining
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7e9ffb55af7f4b2f9a5cfebaf60ef6ca
work_keys_str_mv AT jakamp brca1associatedstructuralvariationsareaconsequenceofpolymerasethetamediatedendjoining
AT rvanschendel brca1associatedstructuralvariationsareaconsequenceofpolymerasethetamediatedendjoining
AT iwdilweg brca1associatedstructuralvariationsareaconsequenceofpolymerasethetamediatedendjoining
AT mtijsterman brca1associatedstructuralvariationsareaconsequenceofpolymerasethetamediatedendjoining
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