Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse

Abstract Exposure to childhood adverse events is associated with severe consequences for general health and structural and functional changes in the brain of its survivors. In order to unravel and in the end influence the pathway linking adversity and pathology, neuroimaging research is crucial. Up...

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Autores principales:	Mirjam A. Rinne-Albers, Charlotte P. Boateng, Steven J. van der Werff, Francien Lamers-Winkelman, Serge A. Rombouts, Robert R. Vermeiren, Nic J. van der Wee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ea08dccc13e47169022951c6b88bb0a
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spelling	oai:doaj.org-article:7ea08dccc13e47169022951c6b88bb0a2021-12-02T11:02:17ZPreserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse10.1038/s41598-020-60256-32045-2322https://doaj.org/article/7ea08dccc13e47169022951c6b88bb0a2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-60256-3https://doaj.org/toc/2045-2322Abstract Exposure to childhood adverse events is associated with severe consequences for general health and structural and functional changes in the brain of its survivors. In order to unravel and in the end influence the pathway linking adversity and pathology, neuroimaging research is crucial. Up till now studies in minors are scarce and differ in type of adversity or methodology. Almost all studies report lower cortical thickness, but in a broad variety of regions. In this study we investigated cortical thickness measures and clinical data in a well circumscribed group of adolescents with PTSD related to childhood sexual abuse (CSA) (N = 21) and a healthy non-traumatised control group (N = 21). The ventromedial PFC (vmPFC), ACC, insula, and middle/superior temporal gyrus were chosen as ROI’s due to their respective roles in emotion and information processing. No significant effect of group was found for cortical thickness, surface area or volume in any of the ROIs. This is in line with the results of research in adult women with sexual abuse related PTSD, suggesting that this may be specific to this group, independent of age. Recent research points to differential biological and pathological consequences of different types of childhood adversity.Mirjam A. Rinne-AlbersCharlotte P. BoatengSteven J. van der WerffFrancien Lamers-WinkelmanSerge A. RomboutsRobert R. VermeirenNic J. van der WeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mirjam A. Rinne-Albers Charlotte P. Boateng Steven J. van der Werff Francien Lamers-Winkelman Serge A. Rombouts Robert R. Vermeiren Nic J. van der Wee Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse
description	Abstract Exposure to childhood adverse events is associated with severe consequences for general health and structural and functional changes in the brain of its survivors. In order to unravel and in the end influence the pathway linking adversity and pathology, neuroimaging research is crucial. Up till now studies in minors are scarce and differ in type of adversity or methodology. Almost all studies report lower cortical thickness, but in a broad variety of regions. In this study we investigated cortical thickness measures and clinical data in a well circumscribed group of adolescents with PTSD related to childhood sexual abuse (CSA) (N = 21) and a healthy non-traumatised control group (N = 21). The ventromedial PFC (vmPFC), ACC, insula, and middle/superior temporal gyrus were chosen as ROI’s due to their respective roles in emotion and information processing. No significant effect of group was found for cortical thickness, surface area or volume in any of the ROIs. This is in line with the results of research in adult women with sexual abuse related PTSD, suggesting that this may be specific to this group, independent of age. Recent research points to differential biological and pathological consequences of different types of childhood adversity.
format	article
author	Mirjam A. Rinne-Albers Charlotte P. Boateng Steven J. van der Werff Francien Lamers-Winkelman Serge A. Rombouts Robert R. Vermeiren Nic J. van der Wee
author_facet	Mirjam A. Rinne-Albers Charlotte P. Boateng Steven J. van der Werff Francien Lamers-Winkelman Serge A. Rombouts Robert R. Vermeiren Nic J. van der Wee
author_sort	Mirjam A. Rinne-Albers
title	Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse
title_short	Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse
title_full	Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse
title_fullStr	Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse
title_full_unstemmed	Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse
title_sort	preserved cortical thickness, surface area and volume in adolescents with ptsd after childhood sexual abuse
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7ea08dccc13e47169022951c6b88bb0a
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Preserved cortical thickness, surface area and volume in adolescents with PTSD after childhood sexual abuse

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