A rapid access to aliphatic sulfonyl fluorides

Sulfonyl fluorides are important probes in chemical biology and molecular pharmacology. Here, the authors report a mild visible light-mediated decarboxylative fluorosulfonylethylation for the synthesis of aliphatic sulfonyl fluorides from a wide range of carboxylic acids, including natural products...

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Autores principales: Ruting Xu, Tianxiao Xu, Mingcheng Yang, Tianpeng Cao, Saihu Liao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7ea28240741e4a08b4c846b8e2ec626d
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Sumario:Sulfonyl fluorides are important probes in chemical biology and molecular pharmacology. Here, the authors report a mild visible light-mediated decarboxylative fluorosulfonylethylation for the synthesis of aliphatic sulfonyl fluorides from a wide range of carboxylic acids, including natural products and drug derivatives.