A pilot clinical study of the therapeutic antibody against canine PD-1 for advanced spontaneous cancers in dogs

Abstract Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most aggressive tumors bearing poor prognosis due to it...

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Main Authors: Masaya Igase, Yuki Nemoto, Kazuhito Itamoto, Kenji Tani, Munekazu Nakaichi, Masashi Sakurai, Yusuke Sakai, Shunsuke Noguchi, Masahiro Kato, Toshihiro Tsukui, Takuya Mizuno
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/7ea57068e99f4b3d9f9d8844f0926591
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