Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries

Indoleamine 2,3-dioxygenase (IDO) is one of the initial rate-limiting enzymes of the kynurenine pathway (KP), which causes immune suppression and induction of T cell anergy. It is associated with the imbalance of immune homeostasis in numerous diseases including cancer, chronic viral infection, alle...

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Autores principales:	Lingyan Xu, Jiawei Ling, Chang Su, Yu-Wen Su, Yan Xu, Zhenzhou Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	IDO liver injury kynurenine pathway immunoregulation liver diseases Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7eaba4b22cdc4ab29cedd65594f1d750
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spelling	oai:doaj.org-article:7eaba4b22cdc4ab29cedd65594f1d7502021-11-18T06:45:49ZEmerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries2296-858X10.3389/fmed.2021.756435https://doaj.org/article/7eaba4b22cdc4ab29cedd65594f1d7502021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.756435/fullhttps://doaj.org/toc/2296-858XIndoleamine 2,3-dioxygenase (IDO) is one of the initial rate-limiting enzymes of the kynurenine pathway (KP), which causes immune suppression and induction of T cell anergy. It is associated with the imbalance of immune homeostasis in numerous diseases including cancer, chronic viral infection, allergy, and autoimmune diseases. Recently, IDO has extended its role to liver field. In this review, we summarize the dysregulation and potentials of IDO in the emerging field of liver injuries, as well as current challenges for IDO targets. In particular, we discuss unexpected conclusions against previous work published. IDO is induced by pro-inflammatory cytokines in liver dysfunction and exerts an immunosuppressive effect, whereas the improvement of liver injury may require consideration of multiple factors besides IDO.Lingyan XuJiawei LingChang SuYu-Wen SuYu-Wen SuYan XuZhenzhou JiangFrontiers Media S.A.articleIDOliver injurykynurenine pathwayimmunoregulationliver diseasesMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IDO liver injury kynurenine pathway immunoregulation liver diseases Medicine (General) R5-920
spellingShingle	IDO liver injury kynurenine pathway immunoregulation liver diseases Medicine (General) R5-920 Lingyan Xu Jiawei Ling Chang Su Yu-Wen Su Yu-Wen Su Yan Xu Zhenzhou Jiang Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
description	Indoleamine 2,3-dioxygenase (IDO) is one of the initial rate-limiting enzymes of the kynurenine pathway (KP), which causes immune suppression and induction of T cell anergy. It is associated with the imbalance of immune homeostasis in numerous diseases including cancer, chronic viral infection, allergy, and autoimmune diseases. Recently, IDO has extended its role to liver field. In this review, we summarize the dysregulation and potentials of IDO in the emerging field of liver injuries, as well as current challenges for IDO targets. In particular, we discuss unexpected conclusions against previous work published. IDO is induced by pro-inflammatory cytokines in liver dysfunction and exerts an immunosuppressive effect, whereas the improvement of liver injury may require consideration of multiple factors besides IDO.
format	article
author	Lingyan Xu Jiawei Ling Chang Su Yu-Wen Su Yu-Wen Su Yan Xu Zhenzhou Jiang
author_facet	Lingyan Xu Jiawei Ling Chang Su Yu-Wen Su Yu-Wen Su Yan Xu Zhenzhou Jiang
author_sort	Lingyan Xu
title	Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
title_short	Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
title_full	Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
title_fullStr	Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
title_full_unstemmed	Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries
title_sort	emerging roles on immunological effect of indoleamine 2,3-dioxygenase in liver injuries
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7eaba4b22cdc4ab29cedd65594f1d750
work_keys_str_mv	AT lingyanxu emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries AT jiaweiling emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries AT changsu emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries AT yuwensu emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries AT yuwensu emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries AT yanxu emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries AT zhenzhoujiang emergingrolesonimmunologicaleffectofindoleamine23dioxygenaseinliverinjuries
_version_	1718424424269479936

Emerging Roles on Immunological Effect of Indoleamine 2,3-Dioxygenase in Liver Injuries

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