Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults

Introduction: In young adults, the metabolic syndrome is rare. To better assess the risks for future cardiovascular disease, a cardiometabolic score can be used, ranking the disease risk in each subject. The score is a continuous variable summarising the individual z-scores for waist circumference,...

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Autores principales:	Staffan Mårild, Agneta Sjöberg, Kerstin Albertsson-Wikland, John E. Chaplin, Lauren Lissner, Jovanna Dahlgren
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/7eb19ad19f2a431782a37b6916683653
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spelling	oai:doaj.org-article:7eb19ad19f2a431782a37b69166836532021-12-02T12:40:22ZFeatures of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults1662-40251662-403310.1159/000520661https://doaj.org/article/7eb19ad19f2a431782a37b69166836532021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520661https://doaj.org/toc/1662-4025https://doaj.org/toc/1662-4033Introduction: In young adults, the metabolic syndrome is rare. To better assess the risks for future cardiovascular disease, a cardiometabolic score can be used, ranking the disease risk in each subject. The score is a continuous variable summarising the individual z-scores for waist circumference, blood pressure, blood levels of glucose, triglycerides and HDL-cholesterol. Our main aim was to assess the association between early childhood growth and the cardiometabolic score in young adults. Methods: Study participants were recruited among subjects in the longitudinal population-based GrowUp 1990 Gothenburg study. Those with information on weight and length at birth, as well as weight, height, waist circumference, and parental BMI at ten years of age were invited to participate in a health survey at 18-20 years of age. 513 young adults (female 51%) were included. Multivariable linear stepwise regression analysis was applied. Results: The mean (SD) BMI was 22.2 (3.26) in males and 21.3 (2.69) kg/m² in females; the cardiometabolic score was 0.24 (3.12) and -0.22 (3.18), respectively. A statistically significantly higher score (p<0.001) was seen in individuals with metabolic syndrome, as defined by IDF. After controlling for adult lifestyle features, BMI z-score at ten years of age was significant risk factor in both sexes for an elevated cardiometabolic score in early adulthood, mean(SE) beta 0.47(0.19), p=0.014 in males, 0.82(017) p<0.0001 in females. In males, high maternal BMI and low age at adiposity rebound and in females high birth weight were also associated with a statistically significant risk. Additionally, contraceptive use in females was a risk factor for elevated cardiometabolic score and, in males a high lifestyle related index score showed a protective association with the cardiometabolic score. Conclusion: A high BMI z-score at ten years of age is a risk factor for the cardiometabolic state in young adults, an outcome points to the preventive potential of monitoring BMI in ten-year-old schoolchildren. This finding must however be validated in a new large cohort. Moreover, in young adults in whom metabolic syndrome is rare, a cardiometabolic score seems to be a promising approach and potentially a more powerful tool to detect risks for cardiovascular disease later in life, than using metabolic syndrome categorisation.Staffan MårildAgneta SjöbergKerstin Albertsson-WiklandJohn E. ChaplinLauren LissnerJovanna DahlgrenKarger PublishersarticleNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENObesity Facts (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Staffan Mårild Agneta Sjöberg Kerstin Albertsson-Wikland John E. Chaplin Lauren Lissner Jovanna Dahlgren Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
description	Introduction: In young adults, the metabolic syndrome is rare. To better assess the risks for future cardiovascular disease, a cardiometabolic score can be used, ranking the disease risk in each subject. The score is a continuous variable summarising the individual z-scores for waist circumference, blood pressure, blood levels of glucose, triglycerides and HDL-cholesterol. Our main aim was to assess the association between early childhood growth and the cardiometabolic score in young adults. Methods: Study participants were recruited among subjects in the longitudinal population-based GrowUp 1990 Gothenburg study. Those with information on weight and length at birth, as well as weight, height, waist circumference, and parental BMI at ten years of age were invited to participate in a health survey at 18-20 years of age. 513 young adults (female 51%) were included. Multivariable linear stepwise regression analysis was applied. Results: The mean (SD) BMI was 22.2 (3.26) in males and 21.3 (2.69) kg/m² in females; the cardiometabolic score was 0.24 (3.12) and -0.22 (3.18), respectively. A statistically significantly higher score (p<0.001) was seen in individuals with metabolic syndrome, as defined by IDF. After controlling for adult lifestyle features, BMI z-score at ten years of age was significant risk factor in both sexes for an elevated cardiometabolic score in early adulthood, mean(SE) beta 0.47(0.19), p=0.014 in males, 0.82(017) p<0.0001 in females. In males, high maternal BMI and low age at adiposity rebound and in females high birth weight were also associated with a statistically significant risk. Additionally, contraceptive use in females was a risk factor for elevated cardiometabolic score and, in males a high lifestyle related index score showed a protective association with the cardiometabolic score. Conclusion: A high BMI z-score at ten years of age is a risk factor for the cardiometabolic state in young adults, an outcome points to the preventive potential of monitoring BMI in ten-year-old schoolchildren. This finding must however be validated in a new large cohort. Moreover, in young adults in whom metabolic syndrome is rare, a cardiometabolic score seems to be a promising approach and potentially a more powerful tool to detect risks for cardiovascular disease later in life, than using metabolic syndrome categorisation.
format	article
author	Staffan Mårild Agneta Sjöberg Kerstin Albertsson-Wikland John E. Chaplin Lauren Lissner Jovanna Dahlgren
author_facet	Staffan Mårild Agneta Sjöberg Kerstin Albertsson-Wikland John E. Chaplin Lauren Lissner Jovanna Dahlgren
author_sort	Staffan Mårild
title	Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
title_short	Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
title_full	Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
title_fullStr	Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
title_full_unstemmed	Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
title_sort	features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/7eb19ad19f2a431782a37b6916683653
work_keys_str_mv	AT staffanmarild featuresofchildhoodgrowthlifestyleandenvironmentassociatedwithacardiometabolicriskscoreinyoungadults AT agnetasjoberg featuresofchildhoodgrowthlifestyleandenvironmentassociatedwithacardiometabolicriskscoreinyoungadults AT kerstinalbertssonwikland featuresofchildhoodgrowthlifestyleandenvironmentassociatedwithacardiometabolicriskscoreinyoungadults AT johnechaplin featuresofchildhoodgrowthlifestyleandenvironmentassociatedwithacardiometabolicriskscoreinyoungadults AT laurenlissner featuresofchildhoodgrowthlifestyleandenvironmentassociatedwithacardiometabolicriskscoreinyoungadults AT jovannadahlgren featuresofchildhoodgrowthlifestyleandenvironmentassociatedwithacardiometabolicriskscoreinyoungadults
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Features of childhood growth, lifestyle and environment associated with a cardiometabolic risk score in young adults

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