The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.

The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.

<h4>Background</h4>An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predispositio...

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Détails bibliographiques
Auteurs principaux: Hans Dieter Nischalke, Cordula Berger, Carolin Luda, Thomas Berg, Tobias Müller, Frank Grünhage, Frank Lammert, Martin Coenen, Benjamin Krämer, Christian Körner, Natascha Vidovic, Johannes Oldenburg, Jacob Nattermann, Tilman Sauerbruch, Ulrich Spengler
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/7eb1b9d661c04ff89accb593ab8daa1b
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https://doaj.org/article/7eb1b9d661c04ff89accb593ab8daa1b

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