SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7eb1ed3741cc4fbfa366937b0037cc35 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7eb1ed3741cc4fbfa366937b0037cc352021-12-02T19:16:51ZSARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate10.1038/s41467-020-18764-32041-1723https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc352020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18764-3https://doaj.org/toc/2041-1723Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.David OlagnierEnsieh FarahaniJacob ThyrstedJulia Blay-CadanetAngela HerengtManja IdornAlon HaitBruno HernaezAlice KnudsenMarie Beck IversenMirjam SchillingSofie E. JørgensenMichelle ThomsenLine S. ReinertMichael LappeHuy-Dung HoangVictoria H. GilchristAnne Louise HansenRasmus OttosenCamilla G. NielsenCharlotte MøllerDemi van der HorstSuraj PeriSiddharth BalachandranJinrong HuangMartin JakobsenEsben B. SvenningsenThomas B. PoulsenLydia BartschAnne L. ThielkeYonglun LuoTommy AlainJan RehwinkelAntonio AlcamíJohn HiscottTrine H. MogensenSøren R. PaludanChristian K. HolmNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David Olagnier Ensieh Farahani Jacob Thyrsted Julia Blay-Cadanet Angela Herengt Manja Idorn Alon Hait Bruno Hernaez Alice Knudsen Marie Beck Iversen Mirjam Schilling Sofie E. Jørgensen Michelle Thomsen Line S. Reinert Michael Lappe Huy-Dung Hoang Victoria H. Gilchrist Anne Louise Hansen Rasmus Ottosen Camilla G. Nielsen Charlotte Møller Demi van der Horst Suraj Peri Siddharth Balachandran Jinrong Huang Martin Jakobsen Esben B. Svenningsen Thomas B. Poulsen Lydia Bartsch Anne L. Thielke Yonglun Luo Tommy Alain Jan Rehwinkel Antonio Alcamí John Hiscott Trine H. Mogensen Søren R. Paludan Christian K. Holm SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| description |
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection. |
| format |
article |
| author |
David Olagnier Ensieh Farahani Jacob Thyrsted Julia Blay-Cadanet Angela Herengt Manja Idorn Alon Hait Bruno Hernaez Alice Knudsen Marie Beck Iversen Mirjam Schilling Sofie E. Jørgensen Michelle Thomsen Line S. Reinert Michael Lappe Huy-Dung Hoang Victoria H. Gilchrist Anne Louise Hansen Rasmus Ottosen Camilla G. Nielsen Charlotte Møller Demi van der Horst Suraj Peri Siddharth Balachandran Jinrong Huang Martin Jakobsen Esben B. Svenningsen Thomas B. Poulsen Lydia Bartsch Anne L. Thielke Yonglun Luo Tommy Alain Jan Rehwinkel Antonio Alcamí John Hiscott Trine H. Mogensen Søren R. Paludan Christian K. Holm |
| author_facet |
David Olagnier Ensieh Farahani Jacob Thyrsted Julia Blay-Cadanet Angela Herengt Manja Idorn Alon Hait Bruno Hernaez Alice Knudsen Marie Beck Iversen Mirjam Schilling Sofie E. Jørgensen Michelle Thomsen Line S. Reinert Michael Lappe Huy-Dung Hoang Victoria H. Gilchrist Anne Louise Hansen Rasmus Ottosen Camilla G. Nielsen Charlotte Møller Demi van der Horst Suraj Peri Siddharth Balachandran Jinrong Huang Martin Jakobsen Esben B. Svenningsen Thomas B. Poulsen Lydia Bartsch Anne L. Thielke Yonglun Luo Tommy Alain Jan Rehwinkel Antonio Alcamí John Hiscott Trine H. Mogensen Søren R. Paludan Christian K. Holm |
| author_sort |
David Olagnier |
| title |
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| title_short |
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| title_full |
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| title_fullStr |
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| title_full_unstemmed |
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| title_sort |
sars-cov2-mediated suppression of nrf2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35 |
| work_keys_str_mv |
AT davidolagnier sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT ensiehfarahani sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT jacobthyrsted sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT juliablaycadanet sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT angelaherengt sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT manjaidorn sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT alonhait sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT brunohernaez sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT aliceknudsen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT mariebeckiversen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT mirjamschilling sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT sofieejørgensen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT michellethomsen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT linesreinert sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT michaellappe sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT huydunghoang sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT victoriahgilchrist sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT annelouisehansen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT rasmusottosen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT camillagnielsen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT charlottemøller sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT demivanderhorst sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT surajperi sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT siddharthbalachandran sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT jinronghuang sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT martinjakobsen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT esbenbsvenningsen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT thomasbpoulsen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT lydiabartsch sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT annelthielke sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT yonglunluo sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT tommyalain sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT janrehwinkel sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT antonioalcami sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT johnhiscott sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT trinehmogensen sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT sørenrpaludan sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate AT christiankholm sarscov2mediatedsuppressionofnrf2signalingrevealspotentantiviralandantiinflammatoryactivityof4octylitaconateanddimethylfumarate |
| _version_ |
1718376922090569728 |