Respiratory virus deterrence induced by modified mask filter.

Airborne transmission of infectious respiratory pathogens is a significant health hazard for the general public as well as healthcare professionals. Face masks have been frequently utilized as safety measures to limit the transmission of these infectious aerosolized particles. However, the efficacy...

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Autores principales:	Su-Hwa Lee, Ki-Back Chu, Hae-Ji Kang, Min-Ju Kim, Eun-Kyung Moon, Fu-Shi Quan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7eb3fc6aa1474e7fa0e744ccb8e3fc05
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spelling	oai:doaj.org-article:7eb3fc6aa1474e7fa0e744ccb8e3fc052021-12-02T20:13:54ZRespiratory virus deterrence induced by modified mask filter.1932-620310.1371/journal.pone.0257827https://doaj.org/article/7eb3fc6aa1474e7fa0e744ccb8e3fc052021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257827https://doaj.org/toc/1932-6203Airborne transmission of infectious respiratory pathogens is a significant health hazard for the general public as well as healthcare professionals. Face masks have been frequently utilized as safety measures to limit the transmission of these infectious aerosolized particles. However, the efficacy of face masks in reducing respiratory virus infectivity and pathogenicity is unknown. Improving the effectiveness of masks in blocking viruses is urgently needed. In this study, surgical mask filters were modified by coating the filters with 1, 3, or 5 M of sodium dihydrogen phosphate, and subsequently exposed to the aerosolized respiratory influenza viruses (A/H3N2, A/H5N1) generated by a nebulizer set. Mask filter modification significantly reduced the size and counts of filter pores, which enabled entrapment of 40-60% of aerosolized viruses (captured viruses) with more than 90% of the captured viruses losing their infectivity. Upon contact with the coated mask filters, both the captured viruses and the viruses that managed to bypass the filter pore (passed viruses) were found to be inactivated. Passed viruses demonstrated significantly reduced pathogenicity in mice as indicated by significantly reduced lung virus titers, bodyweight loss, and prolonged survival compared to bare control. These findings highlight the potential of modified mask filters for reducing viral activity and pathogenicity, which contributes to improving facial mask efficacy as well as limiting airborne pathogen transmission.Su-Hwa LeeKi-Back ChuHae-Ji KangMin-Ju KimEun-Kyung MoonFu-Shi QuanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257827 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Su-Hwa Lee Ki-Back Chu Hae-Ji Kang Min-Ju Kim Eun-Kyung Moon Fu-Shi Quan Respiratory virus deterrence induced by modified mask filter.
description	Airborne transmission of infectious respiratory pathogens is a significant health hazard for the general public as well as healthcare professionals. Face masks have been frequently utilized as safety measures to limit the transmission of these infectious aerosolized particles. However, the efficacy of face masks in reducing respiratory virus infectivity and pathogenicity is unknown. Improving the effectiveness of masks in blocking viruses is urgently needed. In this study, surgical mask filters were modified by coating the filters with 1, 3, or 5 M of sodium dihydrogen phosphate, and subsequently exposed to the aerosolized respiratory influenza viruses (A/H3N2, A/H5N1) generated by a nebulizer set. Mask filter modification significantly reduced the size and counts of filter pores, which enabled entrapment of 40-60% of aerosolized viruses (captured viruses) with more than 90% of the captured viruses losing their infectivity. Upon contact with the coated mask filters, both the captured viruses and the viruses that managed to bypass the filter pore (passed viruses) were found to be inactivated. Passed viruses demonstrated significantly reduced pathogenicity in mice as indicated by significantly reduced lung virus titers, bodyweight loss, and prolonged survival compared to bare control. These findings highlight the potential of modified mask filters for reducing viral activity and pathogenicity, which contributes to improving facial mask efficacy as well as limiting airborne pathogen transmission.
format	article
author	Su-Hwa Lee Ki-Back Chu Hae-Ji Kang Min-Ju Kim Eun-Kyung Moon Fu-Shi Quan
author_facet	Su-Hwa Lee Ki-Back Chu Hae-Ji Kang Min-Ju Kim Eun-Kyung Moon Fu-Shi Quan
author_sort	Su-Hwa Lee
title	Respiratory virus deterrence induced by modified mask filter.
title_short	Respiratory virus deterrence induced by modified mask filter.
title_full	Respiratory virus deterrence induced by modified mask filter.
title_fullStr	Respiratory virus deterrence induced by modified mask filter.
title_full_unstemmed	Respiratory virus deterrence induced by modified mask filter.
title_sort	respiratory virus deterrence induced by modified mask filter.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7eb3fc6aa1474e7fa0e744ccb8e3fc05
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Respiratory virus deterrence induced by modified mask filter.

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