Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

Bioprinting stem cells into three-dimensional (3D) scaffolds has emerged as a new avenue for regenerative medicine, bone tissue engineering, and biosensor manufacturing in recent years. Mesenchymal stem cells, such as adipose-derived and bone-marrow-derived stem cells, are capable of multipotent dif...

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Autores principales:	Shebin Tharakan, Shams Khondkar, Azhar Ilyas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bioprinting stem cells composite biomaterials osteogenesis fracture repair Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/7ebda58c4001497b8799eb7607db9807
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spelling	oai:doaj.org-article:7ebda58c4001497b8799eb7607db98072021-11-25T18:56:45ZBioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering10.3390/s212274771424-8220https://doaj.org/article/7ebda58c4001497b8799eb7607db98072021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7477https://doaj.org/toc/1424-8220Bioprinting stem cells into three-dimensional (3D) scaffolds has emerged as a new avenue for regenerative medicine, bone tissue engineering, and biosensor manufacturing in recent years. Mesenchymal stem cells, such as adipose-derived and bone-marrow-derived stem cells, are capable of multipotent differentiation in a 3D culture. The use of different printing methods results in varying effects on the bioprinted stem cells with the appearance of no general adverse effects. Specifically, extrusion, inkjet, and laser-assisted bioprinting are three methods that impact stem cell viability, proliferation, and differentiation potential. Each printing method confers advantages and disadvantages that directly influence cellular behavior. Additionally, the acquisition of 3D bioprinters has become more prominent with innovative technology and affordability. With accessible technology, custom 3D bioprinters with capabilities to print high-performance bioinks are used for biosensor fabrication. Such 3D printed biosensors are used to control conductivity and electrical transmission in physiological environments. Once printed, the scaffolds containing the aforementioned stem cells have a significant impact on cellular behavior and differentiation. Natural polymer hydrogels and natural composites can impact osteogenic differentiation with some inducing chondrogenesis. Further studies have shown enhanced osteogenesis using cell-laden scaffolds in vivo. Furthermore, selective use of biomaterials can directly influence cell fate and the quantity of osteogenesis. This review evaluates the impact of extrusion, inkjet, and laser-assisted bioprinting on adipose-derived and bone-marrow-derived stem cells along with the effect of incorporating these stem cells into natural and composite biomaterials.Shebin TharakanShams KhondkarAzhar IlyasMDPI AGarticlebioprintingstem cellscomposite biomaterialsosteogenesisfracture repairChemical technologyTP1-1185ENSensors, Vol 21, Iss 7477, p 7477 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioprinting stem cells composite biomaterials osteogenesis fracture repair Chemical technology TP1-1185
spellingShingle	bioprinting stem cells composite biomaterials osteogenesis fracture repair Chemical technology TP1-1185 Shebin Tharakan Shams Khondkar Azhar Ilyas Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
description	Bioprinting stem cells into three-dimensional (3D) scaffolds has emerged as a new avenue for regenerative medicine, bone tissue engineering, and biosensor manufacturing in recent years. Mesenchymal stem cells, such as adipose-derived and bone-marrow-derived stem cells, are capable of multipotent differentiation in a 3D culture. The use of different printing methods results in varying effects on the bioprinted stem cells with the appearance of no general adverse effects. Specifically, extrusion, inkjet, and laser-assisted bioprinting are three methods that impact stem cell viability, proliferation, and differentiation potential. Each printing method confers advantages and disadvantages that directly influence cellular behavior. Additionally, the acquisition of 3D bioprinters has become more prominent with innovative technology and affordability. With accessible technology, custom 3D bioprinters with capabilities to print high-performance bioinks are used for biosensor fabrication. Such 3D printed biosensors are used to control conductivity and electrical transmission in physiological environments. Once printed, the scaffolds containing the aforementioned stem cells have a significant impact on cellular behavior and differentiation. Natural polymer hydrogels and natural composites can impact osteogenic differentiation with some inducing chondrogenesis. Further studies have shown enhanced osteogenesis using cell-laden scaffolds in vivo. Furthermore, selective use of biomaterials can directly influence cell fate and the quantity of osteogenesis. This review evaluates the impact of extrusion, inkjet, and laser-assisted bioprinting on adipose-derived and bone-marrow-derived stem cells along with the effect of incorporating these stem cells into natural and composite biomaterials.
format	article
author	Shebin Tharakan Shams Khondkar Azhar Ilyas
author_facet	Shebin Tharakan Shams Khondkar Azhar Ilyas
author_sort	Shebin Tharakan
title	Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
title_short	Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
title_full	Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
title_fullStr	Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
title_full_unstemmed	Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering
title_sort	bioprinting of stem cells in multimaterial scaffolds and their applications in bone tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ebda58c4001497b8799eb7607db9807
work_keys_str_mv	AT shebintharakan bioprintingofstemcellsinmultimaterialscaffoldsandtheirapplicationsinbonetissueengineering AT shamskhondkar bioprintingofstemcellsinmultimaterialscaffoldsandtheirapplicationsinbonetissueengineering AT azharilyas bioprintingofstemcellsinmultimaterialscaffoldsandtheirapplicationsinbonetissueengineering
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Bioprinting of Stem Cells in Multimaterial Scaffolds and Their Applications in Bone Tissue Engineering

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