Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a panc...

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Autores principales:	Nuria Cerdá-Esteban, Heike Naumann, Silvia Ruzittu, Nancy Mah, Igor M. Pongrac, Corinna Cozzitorto, Angela Hommel, Miguel A. Andrade-Navarro, Ezio Bonifacio, Francesca M. Spagnoli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ebdf3d8a92040efa4c2ffd160f951bf
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spelling	oai:doaj.org-article:7ebdf3d8a92040efa4c2ffd160f951bf2021-12-02T15:38:31ZStepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif210.1038/ncomms141272041-1723https://doaj.org/article/7ebdf3d8a92040efa4c2ffd160f951bf2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14127https://doaj.org/toc/2041-1723Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a pancreatic fate.Nuria Cerdá-EstebanHeike NaumannSilvia RuzittuNancy MahIgor M. PongracCorinna CozzitortoAngela HommelMiguel A. Andrade-NavarroEzio BonifacioFrancesca M. SpagnoliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nuria Cerdá-Esteban Heike Naumann Silvia Ruzittu Nancy Mah Igor M. Pongrac Corinna Cozzitorto Angela Hommel Miguel A. Andrade-Navarro Ezio Bonifacio Francesca M. Spagnoli Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
description	Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a pancreatic fate.
format	article
author	Nuria Cerdá-Esteban Heike Naumann Silvia Ruzittu Nancy Mah Igor M. Pongrac Corinna Cozzitorto Angela Hommel Miguel A. Andrade-Navarro Ezio Bonifacio Francesca M. Spagnoli
author_facet	Nuria Cerdá-Esteban Heike Naumann Silvia Ruzittu Nancy Mah Igor M. Pongrac Corinna Cozzitorto Angela Hommel Miguel A. Andrade-Navarro Ezio Bonifacio Francesca M. Spagnoli
author_sort	Nuria Cerdá-Esteban
title	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
title_short	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
title_full	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
title_fullStr	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
title_full_unstemmed	Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
title_sort	stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator tgif2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7ebdf3d8a92040efa4c2ffd160f951bf
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Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

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