Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer

Objective. To analyze the efficacy of androgen deprivation therapy (ADT) combined with radiation therapy (also known as radiotherapy) for prostate cancer. Methods. The clinical data of 94 prostate cancer patients treated in the Oncology Department of Xiangzhou People’s Hospital from January 2017 to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Siping Zeng, Gangyun Guan, Qiuwei Qin, Huadong Xie, Yongyan Meng, Qiyue Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/7ebe4c3e46764b169da9ceb740ad66b0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7ebe4c3e46764b169da9ceb740ad66b0
record_format	dspace
spelling	oai:doaj.org-article:7ebe4c3e46764b169da9ceb740ad66b02021-11-22T01:10:18ZEfficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer1741-428810.1155/2021/2237069https://doaj.org/article/7ebe4c3e46764b169da9ceb740ad66b02021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/2237069https://doaj.org/toc/1741-4288Objective. To analyze the efficacy of androgen deprivation therapy (ADT) combined with radiation therapy (also known as radiotherapy) for prostate cancer. Methods. The clinical data of 94 prostate cancer patients treated in the Oncology Department of Xiangzhou People’s Hospital from January 2017 to January 2018 were retrospectively analyzed, and the patients were divided into the combined group and the reference group according to their admission order, with 47 cases each. The patients in the reference group only received the radiotherapy, and on this basis, those in the combined group accepted ADT, so as to evaluate the efficacy of different treatment methods by comparing the patients’ serum total prostate-specific antigen (T-PSA), vascular endothelial growth factor (VEGF), and other indicators and analyze the relevant factors affecting patients’ prognosis by Cox single-factor and multi-factor regression models. Results. Compared with the reference group after treatment, the patients in the combined group obtained significantly lower T-PSA and VEGF levels (P<0.001), significantly higher objective remission rate and disease control rate (P<0.05), and remarkably longer modified progression-free survival (mPFS) and overall survival (OS) (P<0.001), and after the multi-factor research, it was found that the Gleason score of 8–10, positive lymphatic metastasis, and single radiotherapy were the factors affecting the clinical prognosis of prostate cancer. Conclusion. Combining ADT with radiotherapy ensures a better survival benefit for prostate cancer patients and has a fairly well efficacy. Further study will be conducive to establishing a better solution for such patients.Siping ZengGangyun GuanQiuwei QinHuadong XieYongyan MengQiyue ZhaoHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Siping Zeng Gangyun Guan Qiuwei Qin Huadong Xie Yongyan Meng Qiyue Zhao Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer
description	Objective. To analyze the efficacy of androgen deprivation therapy (ADT) combined with radiation therapy (also known as radiotherapy) for prostate cancer. Methods. The clinical data of 94 prostate cancer patients treated in the Oncology Department of Xiangzhou People’s Hospital from January 2017 to January 2018 were retrospectively analyzed, and the patients were divided into the combined group and the reference group according to their admission order, with 47 cases each. The patients in the reference group only received the radiotherapy, and on this basis, those in the combined group accepted ADT, so as to evaluate the efficacy of different treatment methods by comparing the patients’ serum total prostate-specific antigen (T-PSA), vascular endothelial growth factor (VEGF), and other indicators and analyze the relevant factors affecting patients’ prognosis by Cox single-factor and multi-factor regression models. Results. Compared with the reference group after treatment, the patients in the combined group obtained significantly lower T-PSA and VEGF levels (P<0.001), significantly higher objective remission rate and disease control rate (P<0.05), and remarkably longer modified progression-free survival (mPFS) and overall survival (OS) (P<0.001), and after the multi-factor research, it was found that the Gleason score of 8–10, positive lymphatic metastasis, and single radiotherapy were the factors affecting the clinical prognosis of prostate cancer. Conclusion. Combining ADT with radiotherapy ensures a better survival benefit for prostate cancer patients and has a fairly well efficacy. Further study will be conducive to establishing a better solution for such patients.
format	article
author	Siping Zeng Gangyun Guan Qiuwei Qin Huadong Xie Yongyan Meng Qiyue Zhao
author_facet	Siping Zeng Gangyun Guan Qiuwei Qin Huadong Xie Yongyan Meng Qiyue Zhao
author_sort	Siping Zeng
title	Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer
title_short	Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer
title_full	Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer
title_fullStr	Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer
title_full_unstemmed	Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer
title_sort	efficacy and prognostic factors of androgen deprivation therapy combined with radiation therapy for prostate cancer
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/7ebe4c3e46764b169da9ceb740ad66b0
work_keys_str_mv	AT sipingzeng efficacyandprognosticfactorsofandrogendeprivationtherapycombinedwithradiationtherapyforprostatecancer AT gangyunguan efficacyandprognosticfactorsofandrogendeprivationtherapycombinedwithradiationtherapyforprostatecancer AT qiuweiqin efficacyandprognosticfactorsofandrogendeprivationtherapycombinedwithradiationtherapyforprostatecancer AT huadongxie efficacyandprognosticfactorsofandrogendeprivationtherapycombinedwithradiationtherapyforprostatecancer AT yongyanmeng efficacyandprognosticfactorsofandrogendeprivationtherapycombinedwithradiationtherapyforprostatecancer AT qiyuezhao efficacyandprognosticfactorsofandrogendeprivationtherapycombinedwithradiationtherapyforprostatecancer
_version_	1718418348416434176

Efficacy and Prognostic Factors of Androgen Deprivation Therapy Combined with Radiation Therapy for Prostate Cancer

Ejemplares similares