Glomerular function in relation to fine airborne particulate matter in a representative population sample

Abstract From 1990 until 2017, global air-pollution related mortality increased by 40%. Few studies addressed the renal responses to ultrafine particulate [≤ 2.5 µm (PM2.5)], including black carbon (BC), which penetrate into the blood stream. In a Flemish population study, glomerular filtration esti...

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Autores principales:	Ying-Mei Feng, Lutgarde Thijs, Zhen-Yu Zhang, Esmée M. Bijnens, Wen-Yi Yang, Fang-Fei Wei, Bram G. Janssen, Tim S. Nawrot, Jan A. Staessen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ec01b939961419b82ffd20a12eba225
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spelling	oai:doaj.org-article:7ec01b939961419b82ffd20a12eba2252021-12-02T16:50:23ZGlomerular function in relation to fine airborne particulate matter in a representative population sample10.1038/s41598-021-94136-12045-2322https://doaj.org/article/7ec01b939961419b82ffd20a12eba2252021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94136-1https://doaj.org/toc/2045-2322Abstract From 1990 until 2017, global air-pollution related mortality increased by 40%. Few studies addressed the renal responses to ultrafine particulate [≤ 2.5 µm (PM2.5)], including black carbon (BC), which penetrate into the blood stream. In a Flemish population study, glomerular filtration estimated from serum creatinine (eGFR) and the urinary albumin-to-creatinine ratio were measured in 2005–2009 in 820 participants (women, 50.7%; age, 51.1 years) with follow-up of 523 after 4.7 years (median). Serum creatinine, eGFR, chronic kidney disease (eGFR < 60 mL/min/1.73 m2) and microalbuminuria (> 3.5/> 2.5 mg per mmol creatinine in women/men) were correlated in individual participants via their residential address with PM2.5 [median 13.1 (range 0.3–2.9) μg/m3] and BC [1.1 (0.3–18) μg/m3], using mixed models accounting for address clusters. Cross-sectional and longitudinally, no renal outcome was associated with PM2.5 or BC in models adjusted for sex and baseline or time varying covariables, including age, blood pressure, heart rate, body mass index, plasma glucose, the total-to-HDL serum cholesterol ratio, alcohol intake, smoking, physical activity, socioeconomic class, and antihypertensive treatment. The subject-level geocorrelations of eGFR change with to BC and PM2.5 were 0.13 and 0.02, respectively (P ≥ 0.68). In conclusion, in a population with moderate exposure, renal function was unrelated to ultrafine particulate.Ying-Mei FengLutgarde ThijsZhen-Yu ZhangEsmée M. BijnensWen-Yi YangFang-Fei WeiBram G. JanssenTim S. NawrotJan A. StaessenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Mei Feng Lutgarde Thijs Zhen-Yu Zhang Esmée M. Bijnens Wen-Yi Yang Fang-Fei Wei Bram G. Janssen Tim S. Nawrot Jan A. Staessen Glomerular function in relation to fine airborne particulate matter in a representative population sample
description	Abstract From 1990 until 2017, global air-pollution related mortality increased by 40%. Few studies addressed the renal responses to ultrafine particulate [≤ 2.5 µm (PM2.5)], including black carbon (BC), which penetrate into the blood stream. In a Flemish population study, glomerular filtration estimated from serum creatinine (eGFR) and the urinary albumin-to-creatinine ratio were measured in 2005–2009 in 820 participants (women, 50.7%; age, 51.1 years) with follow-up of 523 after 4.7 years (median). Serum creatinine, eGFR, chronic kidney disease (eGFR < 60 mL/min/1.73 m2) and microalbuminuria (> 3.5/> 2.5 mg per mmol creatinine in women/men) were correlated in individual participants via their residential address with PM2.5 [median 13.1 (range 0.3–2.9) μg/m3] and BC [1.1 (0.3–18) μg/m3], using mixed models accounting for address clusters. Cross-sectional and longitudinally, no renal outcome was associated with PM2.5 or BC in models adjusted for sex and baseline or time varying covariables, including age, blood pressure, heart rate, body mass index, plasma glucose, the total-to-HDL serum cholesterol ratio, alcohol intake, smoking, physical activity, socioeconomic class, and antihypertensive treatment. The subject-level geocorrelations of eGFR change with to BC and PM2.5 were 0.13 and 0.02, respectively (P ≥ 0.68). In conclusion, in a population with moderate exposure, renal function was unrelated to ultrafine particulate.
format	article
author	Ying-Mei Feng Lutgarde Thijs Zhen-Yu Zhang Esmée M. Bijnens Wen-Yi Yang Fang-Fei Wei Bram G. Janssen Tim S. Nawrot Jan A. Staessen
author_facet	Ying-Mei Feng Lutgarde Thijs Zhen-Yu Zhang Esmée M. Bijnens Wen-Yi Yang Fang-Fei Wei Bram G. Janssen Tim S. Nawrot Jan A. Staessen
author_sort	Ying-Mei Feng
title	Glomerular function in relation to fine airborne particulate matter in a representative population sample
title_short	Glomerular function in relation to fine airborne particulate matter in a representative population sample
title_full	Glomerular function in relation to fine airborne particulate matter in a representative population sample
title_fullStr	Glomerular function in relation to fine airborne particulate matter in a representative population sample
title_full_unstemmed	Glomerular function in relation to fine airborne particulate matter in a representative population sample
title_sort	glomerular function in relation to fine airborne particulate matter in a representative population sample
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ec01b939961419b82ffd20a12eba225
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Glomerular function in relation to fine airborne particulate matter in a representative population sample

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