Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study

Background Mucinous adenocarcinoma accounts for approximately 5% - 15% of all colorectal cancers. Objectives The aim of this study was to investigate the clinicopathological characteristics of patients with mucinous colorectal adenocarcinoma. Patients and Methods This retrospective study wa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sare Hosseini, Shadi Zohourinia, Mohammad Zare-Bandamiri, Maral Mokhtari, Soudabeh Pourhashemi, Massood Hosseinzadeh, Mohammad Mohammadianpanah
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2016
Materias:	colorectal cancer mucinous adenocarcinoma pathology characteristics Medicine R
Acceso en línea:	https://doaj.org/article/7ec0547965d648fba7119532e1f06ac7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7ec0547965d648fba7119532e1f06ac7
record_format	dspace
spelling	oai:doaj.org-article:7ec0547965d648fba7119532e1f06ac72021-11-15T09:43:49ZClinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study2783-243010.17795/acr-34404https://doaj.org/article/7ec0547965d648fba7119532e1f06ac72016-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45508_2d2c8cadc19f89ad39d0784fa2995421.pdfhttps://doaj.org/toc/2783-2430Background Mucinous adenocarcinoma accounts for approximately 5% - 15% of all colorectal cancers. Objectives The aim of this study was to investigate the clinicopathological characteristics of patients with mucinous colorectal adenocarcinoma. Patients and Methods This retrospective study was carried out by reviewing the medical records of 70 mucinous colorectal cancer (MCC) patients who were diagnosed and treated at a tertiary academic hospital between 2005 and 2010. For the comparative analysis, 491 patients with non-mucinous colorectal cancer (NMCC) were included. Results Of 561 patients with colorectal adenocarcinoma, 70 patients (12.5%) had the mucinous type. There were 42 (60%) men and 28 (40%) women, with a median age of 55 years old (range 24 - 81 years) included in the study. We did not find any differences regarding the patients’ mean age (P = 0.408) and male/female ratio (P = 0.700) between the MCC and NMCC; however, there was a predilection for the right colon and sigmoid colon in the MCC, when compared to the NMCC (P = 0.012). In addition, the MCC tended to have a larger tumor size (P = 0.004), higher histological grade (P < 0.001), higher node stage (P < 0.001), higher number of dissected nodes (P = 0.013), higher number of positive nodes (P < 0.001), and a higher rate of perineural invasion (P = 0.013) compared to the NMCC. Conclusions This study indicates that most clinicopathological characteristics of MCC are different from those of NMCC. In addition, there was an association between the mucinous subtype and adverse pathological features in the patients with colorectal cancer.Sare HosseiniShadi ZohouriniaMohammad Zare-BandamiriMaral MokhtariSoudabeh PourhashemiMassood HosseinzadehMohammad MohammadianpanahShiraz University of Medical Sciencesarticlecolorectal cancermucinous adenocarcinomapathologycharacteristicsMedicineRENIranian Journal of Colorectal Research, Vol 4, Iss 1, Pp 0-0 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer mucinous adenocarcinoma pathology characteristics Medicine R
spellingShingle	colorectal cancer mucinous adenocarcinoma pathology characteristics Medicine R Sare Hosseini Shadi Zohourinia Mohammad Zare-Bandamiri Maral Mokhtari Soudabeh Pourhashemi Massood Hosseinzadeh Mohammad Mohammadianpanah Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study
description	Background Mucinous adenocarcinoma accounts for approximately 5% - 15% of all colorectal cancers. Objectives The aim of this study was to investigate the clinicopathological characteristics of patients with mucinous colorectal adenocarcinoma. Patients and Methods This retrospective study was carried out by reviewing the medical records of 70 mucinous colorectal cancer (MCC) patients who were diagnosed and treated at a tertiary academic hospital between 2005 and 2010. For the comparative analysis, 491 patients with non-mucinous colorectal cancer (NMCC) were included. Results Of 561 patients with colorectal adenocarcinoma, 70 patients (12.5%) had the mucinous type. There were 42 (60%) men and 28 (40%) women, with a median age of 55 years old (range 24 - 81 years) included in the study. We did not find any differences regarding the patients’ mean age (P = 0.408) and male/female ratio (P = 0.700) between the MCC and NMCC; however, there was a predilection for the right colon and sigmoid colon in the MCC, when compared to the NMCC (P = 0.012). In addition, the MCC tended to have a larger tumor size (P = 0.004), higher histological grade (P < 0.001), higher node stage (P < 0.001), higher number of dissected nodes (P = 0.013), higher number of positive nodes (P < 0.001), and a higher rate of perineural invasion (P = 0.013) compared to the NMCC. Conclusions This study indicates that most clinicopathological characteristics of MCC are different from those of NMCC. In addition, there was an association between the mucinous subtype and adverse pathological features in the patients with colorectal cancer.
format	article
author	Sare Hosseini Shadi Zohourinia Mohammad Zare-Bandamiri Maral Mokhtari Soudabeh Pourhashemi Massood Hosseinzadeh Mohammad Mohammadianpanah
author_facet	Sare Hosseini Shadi Zohourinia Mohammad Zare-Bandamiri Maral Mokhtari Soudabeh Pourhashemi Massood Hosseinzadeh Mohammad Mohammadianpanah
author_sort	Sare Hosseini
title	Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study
title_short	Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study
title_full	Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study
title_fullStr	Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study
title_full_unstemmed	Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study
title_sort	clinical and pathological characteristics of mucinous colorectal adenocarcinoma: a comparative study
publisher	Shiraz University of Medical Sciences
publishDate	2016
url	https://doaj.org/article/7ec0547965d648fba7119532e1f06ac7
work_keys_str_mv	AT sarehosseini clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy AT shadizohourinia clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy AT mohammadzarebandamiri clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy AT maralmokhtari clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy AT soudabehpourhashemi clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy AT massoodhosseinzadeh clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy AT mohammadmohammadianpanah clinicalandpathologicalcharacteristicsofmucinouscolorectaladenocarcinomaacomparativestudy
_version_	1718428504883724288

Clinical and Pathological Characteristics of Mucinous Colorectal Adenocarcinoma: A Comparative Study

Ejemplares similares