Impact of middle-of-the-night awakenings on health status, activity impairment, and costs

Margaret Moline,1 Marco daCosta DiBonaventura,2 Dhvani Shah,1 Rami Ben-Joseph1 1Purdue Pharma, LP, Stamford, CT, USA; 2Health Outcomes Practice, Kantar Health, New York, NY, USA Study objectives: Middle-of-the-night (MOTN) awakenings with difficulty returning to sleep are among the most common sym...

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Autores principales:	Moline M, DiBonaventura MD, Shah D, Ben-Joseph R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/7ec9ab7e6b4a44dd86225f2818a405ef
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spelling	oai:doaj.org-article:7ec9ab7e6b4a44dd86225f2818a405ef2021-12-02T01:55:32ZImpact of middle-of-the-night awakenings on health status, activity impairment, and costs1179-1608https://doaj.org/article/7ec9ab7e6b4a44dd86225f2818a405ef2014-07-01T00:00:00Zhttp://www.dovepress.com/impact-of-middle-of-the-night-awakenings-on-health-status-activity-imp-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608 Margaret Moline,1 Marco daCosta DiBonaventura,2 Dhvani Shah,1 Rami Ben-Joseph1 1Purdue Pharma, LP, Stamford, CT, USA; 2Health Outcomes Practice, Kantar Health, New York, NY, USA Study objectives: Middle-of-the-night (MOTN) awakenings with difficulty returning to sleep are among the most common symptoms of insomnia. Despite the epidemiological studies that have been conducted, there is a lack of data on the impact of MOTN awakenings on health status and socioeconomic indicators in comparison with other insomnia symptoms. Methods: Data were analyzed from the 2011 US National Health and Wellness Survey (adults ≥18 years old; N=60,783), which asked respondents whether they had experienced specific symptoms of insomnia (ie, MOTN awakenings, difficulty falling asleep, waking several times, waking up too early, or poor quality of sleep). Respondents who reported only one insomnia symptom were compared among insomnia subgroups and with no insomnia symptom controls with respect to demographics, health history, and health outcomes (Short Form-12v2, Work Productivity and Activity Impairment questionnaire, and costs). Additional analyses compared respondents with only MOTN awakenings and matched controls on health outcomes. Results: MOTN awakenings without other insomnia symptoms were reported by 3.5% of respondents. Poor quality of sleep was associated with the strongest effects on health status compared with other insomnia symptoms even after adjusting for demographic and health characteristics differences. Differences across insomnia symptoms with respect to cost-related outcomes were generally modest, though all were higher (if not significantly so) than respondents without insomnia. Respondents who experienced only waking several times and only MOTN awakenings had the highest direct costs, while respondents who experienced only poor quality of sleep and only difficulty falling asleep had the highest indirect costs. Respondents with only MOTN awakenings reported significantly worse mental and physical health status and worse health utilities relative to insomnia-free matched controls (all P<0.05). Annual per-employee indirect costs were also significantly higher ($4,328 vs $3,000; P<0.05). Among only MOTN awakenings respondents, 74.6% were considered only symptomatic (ie, they did not report having insomnia or having been diagnosed with insomnia). Conclusion: These findings collectively highlight the prevalence and socioeconomic impact of specific types of insomnia symptoms, including MOTN awakenings, experienced by adults in the US. Keywords: insomnia, nocturnal awakenings, work productivity, health outcomes, sleep quality, sleep symptomsMoline MDiBonaventura MDShah DBen-Joseph RDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2014, Iss default, Pp 101-111 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Moline M DiBonaventura MD Shah D Ben-Joseph R Impact of middle-of-the-night awakenings on health status, activity impairment, and costs
description	Margaret Moline,1 Marco daCosta DiBonaventura,2 Dhvani Shah,1 Rami Ben-Joseph1 1Purdue Pharma, LP, Stamford, CT, USA; 2Health Outcomes Practice, Kantar Health, New York, NY, USA Study objectives: Middle-of-the-night (MOTN) awakenings with difficulty returning to sleep are among the most common symptoms of insomnia. Despite the epidemiological studies that have been conducted, there is a lack of data on the impact of MOTN awakenings on health status and socioeconomic indicators in comparison with other insomnia symptoms. Methods: Data were analyzed from the 2011 US National Health and Wellness Survey (adults ≥18 years old; N=60,783), which asked respondents whether they had experienced specific symptoms of insomnia (ie, MOTN awakenings, difficulty falling asleep, waking several times, waking up too early, or poor quality of sleep). Respondents who reported only one insomnia symptom were compared among insomnia subgroups and with no insomnia symptom controls with respect to demographics, health history, and health outcomes (Short Form-12v2, Work Productivity and Activity Impairment questionnaire, and costs). Additional analyses compared respondents with only MOTN awakenings and matched controls on health outcomes. Results: MOTN awakenings without other insomnia symptoms were reported by 3.5% of respondents. Poor quality of sleep was associated with the strongest effects on health status compared with other insomnia symptoms even after adjusting for demographic and health characteristics differences. Differences across insomnia symptoms with respect to cost-related outcomes were generally modest, though all were higher (if not significantly so) than respondents without insomnia. Respondents who experienced only waking several times and only MOTN awakenings had the highest direct costs, while respondents who experienced only poor quality of sleep and only difficulty falling asleep had the highest indirect costs. Respondents with only MOTN awakenings reported significantly worse mental and physical health status and worse health utilities relative to insomnia-free matched controls (all P<0.05). Annual per-employee indirect costs were also significantly higher ($4,328 vs $3,000; P<0.05). Among only MOTN awakenings respondents, 74.6% were considered only symptomatic (ie, they did not report having insomnia or having been diagnosed with insomnia). Conclusion: These findings collectively highlight the prevalence and socioeconomic impact of specific types of insomnia symptoms, including MOTN awakenings, experienced by adults in the US. Keywords: insomnia, nocturnal awakenings, work productivity, health outcomes, sleep quality, sleep symptoms
format	article
author	Moline M DiBonaventura MD Shah D Ben-Joseph R
author_facet	Moline M DiBonaventura MD Shah D Ben-Joseph R
author_sort	Moline M
title	Impact of middle-of-the-night awakenings on health status, activity impairment, and costs
title_short	Impact of middle-of-the-night awakenings on health status, activity impairment, and costs
title_full	Impact of middle-of-the-night awakenings on health status, activity impairment, and costs
title_fullStr	Impact of middle-of-the-night awakenings on health status, activity impairment, and costs
title_full_unstemmed	Impact of middle-of-the-night awakenings on health status, activity impairment, and costs
title_sort	impact of middle-of-the-night awakenings on health status, activity impairment, and costs
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/7ec9ab7e6b4a44dd86225f2818a405ef
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Impact of middle-of-the-night awakenings on health status, activity impairment, and costs

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