Mechanism of microtubule stabilization by taccalonolide AJ

Microtubule-stabilizing agents (MSAs) promote the polymerization of tubulin and are of great interest as anticancer drugs. Here the authors present the crystal structure of the MSA taccalonolide AJ bound to tubulin and give insights into its mode of action, which might help in the design of novel MS...

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Autores principales:	Yuxi Wang, Yamei Yu, Guo-Bo Li, Shu-Ang Li, Chengyong Wu, Benoît Gigant, Wenming Qin, Hao Chen, Yangping Wu, Qiang Chen, Jinliang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7eca1bb82aef4a84b8bbc010e8629fe9
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spelling	oai:doaj.org-article:7eca1bb82aef4a84b8bbc010e8629fe92021-12-02T17:06:20ZMechanism of microtubule stabilization by taccalonolide AJ10.1038/ncomms157872041-1723https://doaj.org/article/7eca1bb82aef4a84b8bbc010e8629fe92017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15787https://doaj.org/toc/2041-1723Microtubule-stabilizing agents (MSAs) promote the polymerization of tubulin and are of great interest as anticancer drugs. Here the authors present the crystal structure of the MSA taccalonolide AJ bound to tubulin and give insights into its mode of action, which might help in the design of novel MSAs.Yuxi WangYamei YuGuo-Bo LiShu-Ang LiChengyong WuBenoît GigantWenming QinHao ChenYangping WuQiang ChenJinliang YangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuxi Wang Yamei Yu Guo-Bo Li Shu-Ang Li Chengyong Wu Benoît Gigant Wenming Qin Hao Chen Yangping Wu Qiang Chen Jinliang Yang Mechanism of microtubule stabilization by taccalonolide AJ
description	Microtubule-stabilizing agents (MSAs) promote the polymerization of tubulin and are of great interest as anticancer drugs. Here the authors present the crystal structure of the MSA taccalonolide AJ bound to tubulin and give insights into its mode of action, which might help in the design of novel MSAs.
format	article
author	Yuxi Wang Yamei Yu Guo-Bo Li Shu-Ang Li Chengyong Wu Benoît Gigant Wenming Qin Hao Chen Yangping Wu Qiang Chen Jinliang Yang
author_facet	Yuxi Wang Yamei Yu Guo-Bo Li Shu-Ang Li Chengyong Wu Benoît Gigant Wenming Qin Hao Chen Yangping Wu Qiang Chen Jinliang Yang
author_sort	Yuxi Wang
title	Mechanism of microtubule stabilization by taccalonolide AJ
title_short	Mechanism of microtubule stabilization by taccalonolide AJ
title_full	Mechanism of microtubule stabilization by taccalonolide AJ
title_fullStr	Mechanism of microtubule stabilization by taccalonolide AJ
title_full_unstemmed	Mechanism of microtubule stabilization by taccalonolide AJ
title_sort	mechanism of microtubule stabilization by taccalonolide aj
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7eca1bb82aef4a84b8bbc010e8629fe9
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_version_	1718381621214707712

Mechanism of microtubule stabilization by taccalonolide AJ

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