Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Selection and characterization of DNA aptamer against glucagon receptor by cell-SELEX

Abstract Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia. Glucagon exerts its physiological functions through activation of the glucagon receptor (GCGR). Inhibition of GCGR activity represents a potential therapeutic approach for reducing...

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Autores principales: Guodong Wang, Jun Liu, Ke Chen, Yiling Xu, Bo Liu, Jie Liao, Lei Zhu, Xiaoxiao Hu, Jianglin Li, Ying Pu, Wen Zhong, Ting Fu, Huixia Liu, Weihong Tan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7ecb0a7671774d3482376e2930725473
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