Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication

High level of population alcoholization is the cause of many cases of acute alcohol and alcoholic surrogate intoxication. The number of alcohol intoxication cases in Kazakhstan in 2014 amounted to 13891 (80.3 per 100 000 people), the number of fatal intoxication cases amounted to 882 (5.1 per 100 00...

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Autores principales:	I. V. Beynikova, V. A. Snytina, L. E. Muravlyova, V. B. Molotov-Luchanskiy, R. E. Bakirova, D. A. Klyuev, L. B. Zhanbyrsheeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	ethanol intoxication alcohol surrogate intoxication oxidative metabolism Science Q
Acceso en línea:	https://doaj.org/article/7ecb6bd47c544a1bad4c11d9a57fefc4
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spelling	oai:doaj.org-article:7ecb6bd47c544a1bad4c11d9a57fefc42021-11-23T06:14:34ZComparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication2541-94202587-959610.12737/article_590823a40412f9.00355582https://doaj.org/article/7ecb6bd47c544a1bad4c11d9a57fefc42016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/176https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596High level of population alcoholization is the cause of many cases of acute alcohol and alcoholic surrogate intoxication. The number of alcohol intoxication cases in Kazakhstan in 2014 amounted to 13891 (80.3 per 100 000 people), the number of fatal intoxication cases amounted to 882 (5.1 per 100 000 people). The problem of alcoholization in Russia remains urgent as well: according to the statistics of 2014,152 551 cases of acute intoxication of chemical etiology were registered, 33.9 % of cases occurred due to alcohol intoxication. Alcoholic beverages in the course of their biotransformation to acetic acid can form oxygen free radicals in particular superoxide anion as a byproduct of acetic aldehyde oxidation reaction. Studies on oxidative metabolism of ethanol intoxication are currently being conducted. At the same time, the state of oxidative metabolism during alcoholic surrogate intoxication was not practically investigated. Evaluation of oxidative metabolism depending on the severity of alcohol or its surrogate intoxication is of special interest. The aim was to compare oxidative metabolism indicators among patients with acute alcohol and alcoholic surrogate intoxication of different severity. The object of the study was blood of 62 people with diagnosed moderate or severe degrees of acute alcohol and alcoholic surrogate intoxication. Indicators of oxidative metabolism in erythrocytes and blood plasma were estimated. Significant differences were found in product concentration of protein oxidation containing bityrosine crosslinks in blood plasma under increase of alcohol intoxication degree.I. V. BeynikovaV. A. SnytinaL. E. MuravlyovaV. B. Molotov-LuchanskiyR. E. BakirovaD. A. KlyuevL. B. ZhanbyrsheevaScientific Сentre for Family Health and Human Reproduction Problemsarticleethanol intoxicationalcohol surrogate intoxicationoxidative metabolismScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 9-11 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	ethanol intoxication alcohol surrogate intoxication oxidative metabolism Science Q
spellingShingle	ethanol intoxication alcohol surrogate intoxication oxidative metabolism Science Q I. V. Beynikova V. A. Snytina L. E. Muravlyova V. B. Molotov-Luchanskiy R. E. Bakirova D. A. Klyuev L. B. Zhanbyrsheeva Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
description	High level of population alcoholization is the cause of many cases of acute alcohol and alcoholic surrogate intoxication. The number of alcohol intoxication cases in Kazakhstan in 2014 amounted to 13891 (80.3 per 100 000 people), the number of fatal intoxication cases amounted to 882 (5.1 per 100 000 people). The problem of alcoholization in Russia remains urgent as well: according to the statistics of 2014,152 551 cases of acute intoxication of chemical etiology were registered, 33.9 % of cases occurred due to alcohol intoxication. Alcoholic beverages in the course of their biotransformation to acetic acid can form oxygen free radicals in particular superoxide anion as a byproduct of acetic aldehyde oxidation reaction. Studies on oxidative metabolism of ethanol intoxication are currently being conducted. At the same time, the state of oxidative metabolism during alcoholic surrogate intoxication was not practically investigated. Evaluation of oxidative metabolism depending on the severity of alcohol or its surrogate intoxication is of special interest. The aim was to compare oxidative metabolism indicators among patients with acute alcohol and alcoholic surrogate intoxication of different severity. The object of the study was blood of 62 people with diagnosed moderate or severe degrees of acute alcohol and alcoholic surrogate intoxication. Indicators of oxidative metabolism in erythrocytes and blood plasma were estimated. Significant differences were found in product concentration of protein oxidation containing bityrosine crosslinks in blood plasma under increase of alcohol intoxication degree.
format	article
author	I. V. Beynikova V. A. Snytina L. E. Muravlyova V. B. Molotov-Luchanskiy R. E. Bakirova D. A. Klyuev L. B. Zhanbyrsheeva
author_facet	I. V. Beynikova V. A. Snytina L. E. Muravlyova V. B. Molotov-Luchanskiy R. E. Bakirova D. A. Klyuev L. B. Zhanbyrsheeva
author_sort	I. V. Beynikova
title	Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
title_short	Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
title_full	Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
title_fullStr	Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
title_full_unstemmed	Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
title_sort	comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/7ecb6bd47c544a1bad4c11d9a57fefc4
work_keys_str_mv	AT ivbeynikova comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication AT vasnytina comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication AT lemuravlyova comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication AT vbmolotovluchanskiy comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication AT rebakirova comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication AT daklyuev comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication AT lbzhanbyrsheeva comparativeanalysisofoxidativemetabolismindicatorsatacutealcoholandacutesurrogatealcoholintoxication
_version_	1718417078562586624

Comparative analysis of oxidative metabolism indicators at acute alcohol and acute surrogate alcohol intoxication

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