Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury

Abstract The purpose of this study is to identify medications with potentially beneficial effects on decreasing mortality in patients with acute kidney injury (AKI) while in the intensive care unit (ICU). We used logistic regression to investigate associations between medications received and ICU mo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaojiang Guo, Xiguang Qi, Peihao Fan, Michael Gilbert, Andrew D. La, Zeyu Liu, Richard Bertz, John A. Kellum, Yu Chen, Lirong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ece5b33bd264adba8600e9e9c147639
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7ece5b33bd264adba8600e9e9c147639
record_format	dspace
spelling	oai:doaj.org-article:7ece5b33bd264adba8600e9e9c1476392021-12-02T19:16:59ZEffect of ondansetron on reducing ICU mortality in patients with acute kidney injury10.1038/s41598-021-98734-x2045-2322https://doaj.org/article/7ece5b33bd264adba8600e9e9c1476392021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98734-xhttps://doaj.org/toc/2045-2322Abstract The purpose of this study is to identify medications with potentially beneficial effects on decreasing mortality in patients with acute kidney injury (AKI) while in the intensive care unit (ICU). We used logistic regression to investigate associations between medications received and ICU mortality in patients with AKI in the MIMIC III database. Drugs associated with reduced mortality were then validated using the eICU database. Propensity score matching (PSM) was used for matching the patients’ baseline severity of illness followed by a chi-square test to calculate the significance of drug use and mortality. Finally, we examined gene expression signatures to explore the drug’s molecular mechanism on AKI. While several drugs demonstrated potential beneficial effects on reducing mortality, most were used for potentially fatal illnesses (e.g. antibiotics, cardiac medications). One exception was found, ondansetron, a drug without previously identified life-saving effects, has correlation with lower mortality among AKI patients. This association was confirmed in a subsequent analysis using the eICU database. Based on the comparison of gene expression signatures, the presumed therapeutic effect of ondansetron may be elicited through the NF-KB pathway and JAK-STAT pathway. Our findings provide real-world evidence to support clinical trials of ondansetron for treatment of AKI.Xiaojiang GuoXiguang QiPeihao FanMichael GilbertAndrew D. LaZeyu LiuRichard BertzJohn A. KellumYu ChenLirong WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaojiang Guo Xiguang Qi Peihao Fan Michael Gilbert Andrew D. La Zeyu Liu Richard Bertz John A. Kellum Yu Chen Lirong Wang Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
description	Abstract The purpose of this study is to identify medications with potentially beneficial effects on decreasing mortality in patients with acute kidney injury (AKI) while in the intensive care unit (ICU). We used logistic regression to investigate associations between medications received and ICU mortality in patients with AKI in the MIMIC III database. Drugs associated with reduced mortality were then validated using the eICU database. Propensity score matching (PSM) was used for matching the patients’ baseline severity of illness followed by a chi-square test to calculate the significance of drug use and mortality. Finally, we examined gene expression signatures to explore the drug’s molecular mechanism on AKI. While several drugs demonstrated potential beneficial effects on reducing mortality, most were used for potentially fatal illnesses (e.g. antibiotics, cardiac medications). One exception was found, ondansetron, a drug without previously identified life-saving effects, has correlation with lower mortality among AKI patients. This association was confirmed in a subsequent analysis using the eICU database. Based on the comparison of gene expression signatures, the presumed therapeutic effect of ondansetron may be elicited through the NF-KB pathway and JAK-STAT pathway. Our findings provide real-world evidence to support clinical trials of ondansetron for treatment of AKI.
format	article
author	Xiaojiang Guo Xiguang Qi Peihao Fan Michael Gilbert Andrew D. La Zeyu Liu Richard Bertz John A. Kellum Yu Chen Lirong Wang
author_facet	Xiaojiang Guo Xiguang Qi Peihao Fan Michael Gilbert Andrew D. La Zeyu Liu Richard Bertz John A. Kellum Yu Chen Lirong Wang
author_sort	Xiaojiang Guo
title	Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
title_short	Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
title_full	Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
title_fullStr	Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
title_full_unstemmed	Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury
title_sort	effect of ondansetron on reducing icu mortality in patients with acute kidney injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ece5b33bd264adba8600e9e9c147639
work_keys_str_mv	AT xiaojiangguo effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT xiguangqi effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT peihaofan effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT michaelgilbert effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT andrewdla effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT zeyuliu effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT richardbertz effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT johnakellum effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT yuchen effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury AT lirongwang effectofondansetrononreducingicumortalityinpatientswithacutekidneyinjury
_version_	1718376922276167680

Effect of ondansetron on reducing ICU mortality in patients with acute kidney injury

Ejemplares similares