Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study

Aim:The purpose of this study was to examine the effects of antiepileptics on thyroid function tests and to compare these effects among different antiepileptics.Materials and Methods:Two hundred and twenty patients (102 female and 118 male) aged 1-17 years indicated for antiepileptic drug (AED) ther...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatma Hancı, Sevim Türay, Keziban Aslı Bala, Aslıhan Tunçlar, Mustafa Dilek, Nimet Kabakuş
Formato:	article
Lenguaje:	EN TR
Publicado:	Galenos Yayinevi 2021
Materias:	antiepileptic drugs children epilepsy thyroid function Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/7eced93b0bea425aa972639c696e021a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7eced93b0bea425aa972639c696e021a
record_format	dspace
spelling	oai:doaj.org-article:7eced93b0bea425aa972639c696e021a2021-11-11T11:27:23ZEffects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study2147-94452587-247810.4274/jpr.galenos.2020.50251https://doaj.org/article/7eced93b0bea425aa972639c696e021a2021-12-01T00:00:00Z http://jpedres.org/archives/archive-detail/article-preview/effects-of-12-month-antiepileptic-drug-use-on-thyr/49627 https://doaj.org/toc/2147-9445https://doaj.org/toc/2587-2478Aim:The purpose of this study was to examine the effects of antiepileptics on thyroid function tests and to compare these effects among different antiepileptics.Materials and Methods:Two hundred and twenty patients (102 female and 118 male) aged 1-17 years indicated for antiepileptic drug (AED) therapy for epilepsy were enrolled in this study which was performed in a child neurology clinic between January 2014 and January 2018. Those patients using a single AED and with complete seizure control were included. In this study period, according to the local protocol, we measured free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels at the beginning of treatment and at the 12th month of AED therapy.Results:The mean age of the patients was 10.2±4.4 years. TSH elevation was observed in only eight patients. These eight patients’ thyroid autoantibodies were negative and their thyroid ultrasonography were normal. Subclinical hypothyroidism (TSH: 5-10, fT4 normal) was present in three of these eight patients, and they were therefore not started on medication. The other five were started on L-thyroxine. Four of these were using valproic acid and one was using carbamazepine. We found no significant difference between TSH and fT4 levels measured before the start and at the 12th month of drug therapy, nor among the different AEDs used.Conclusion:AEDs have no marked effects on thyroid function, and may therefore be safely used from that perspective.Fatma HancıSevim TürayKeziban Aslı BalaAslıhan TunçlarMustafa DilekNimet KabakuşGalenos Yayineviarticleantiepileptic drugschildrenepilepsythyroid functionMedicineRPediatricsRJ1-570ENTRJournal of Pediatric Research, Vol 8, Iss 4, Pp 389-393 (2021)
institution	DOAJ
collection	DOAJ
language	EN TR
topic	antiepileptic drugs children epilepsy thyroid function Medicine R Pediatrics RJ1-570
spellingShingle	antiepileptic drugs children epilepsy thyroid function Medicine R Pediatrics RJ1-570 Fatma Hancı Sevim Türay Keziban Aslı Bala Aslıhan Tunçlar Mustafa Dilek Nimet Kabakuş Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study
description	Aim:The purpose of this study was to examine the effects of antiepileptics on thyroid function tests and to compare these effects among different antiepileptics.Materials and Methods:Two hundred and twenty patients (102 female and 118 male) aged 1-17 years indicated for antiepileptic drug (AED) therapy for epilepsy were enrolled in this study which was performed in a child neurology clinic between January 2014 and January 2018. Those patients using a single AED and with complete seizure control were included. In this study period, according to the local protocol, we measured free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels at the beginning of treatment and at the 12th month of AED therapy.Results:The mean age of the patients was 10.2±4.4 years. TSH elevation was observed in only eight patients. These eight patients’ thyroid autoantibodies were negative and their thyroid ultrasonography were normal. Subclinical hypothyroidism (TSH: 5-10, fT4 normal) was present in three of these eight patients, and they were therefore not started on medication. The other five were started on L-thyroxine. Four of these were using valproic acid and one was using carbamazepine. We found no significant difference between TSH and fT4 levels measured before the start and at the 12th month of drug therapy, nor among the different AEDs used.Conclusion:AEDs have no marked effects on thyroid function, and may therefore be safely used from that perspective.
format	article
author	Fatma Hancı Sevim Türay Keziban Aslı Bala Aslıhan Tunçlar Mustafa Dilek Nimet Kabakuş
author_facet	Fatma Hancı Sevim Türay Keziban Aslı Bala Aslıhan Tunçlar Mustafa Dilek Nimet Kabakuş
author_sort	Fatma Hancı
title	Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study
title_short	Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study
title_full	Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study
title_fullStr	Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study
title_full_unstemmed	Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study
title_sort	effects of 12-month antiepileptic drug use on thyroid functions in children: a retrospective observational study
publisher	Galenos Yayinevi
publishDate	2021
url	https://doaj.org/article/7eced93b0bea425aa972639c696e021a
work_keys_str_mv	AT fatmahancı effectsof12monthantiepilepticdruguseonthyroidfunctionsinchildrenaretrospectiveobservationalstudy AT sevimturay effectsof12monthantiepilepticdruguseonthyroidfunctionsinchildrenaretrospectiveobservationalstudy AT kezibanaslıbala effectsof12monthantiepilepticdruguseonthyroidfunctionsinchildrenaretrospectiveobservationalstudy AT aslıhantunclar effectsof12monthantiepilepticdruguseonthyroidfunctionsinchildrenaretrospectiveobservationalstudy AT mustafadilek effectsof12monthantiepilepticdruguseonthyroidfunctionsinchildrenaretrospectiveobservationalstudy AT nimetkabakus effectsof12monthantiepilepticdruguseonthyroidfunctionsinchildrenaretrospectiveobservationalstudy
_version_	1718439141321998336

Effects of 12-month Antiepileptic Drug Use on Thyroid Functions in Children: A Retrospective Observational Study

Ejemplares similares