Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin

Blanka Sütö,1 Szilvia Berkó,1 Gábor Kozma,2 Ákos Kukovecz,2,3 Mária Budai-Szucs,1 Gábor Erös,4,5 Lajos Kemény,4 Anita Sztojkov-Ivanov,6 Róbert Gáspár,6 Erzsébet Cs...

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Autores principales:	Sütő B, Berkó S, Kozma G, Kukovecz Á, Budai-Szűcs M, Erős G, Kemény L, Sztojkov-Ivanov A, Gáspár R, Csányi E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Ibuprofen Nanostructured lipid carriers Skin penetration SKH-1 hairless mice Osteoarthritis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7ed3fc33b1c846099e7f4e0d12adc1f6
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spelling	oai:doaj.org-article:7ed3fc33b1c846099e7f4e0d12adc1f62021-12-02T00:07:19ZDevelopment of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin1178-2013https://doaj.org/article/7ed3fc33b1c846099e7f4e0d12adc1f62016-03-01T00:00:00Zhttps://www.dovepress.com/development-of-ibuprofen-loaded-nanostructured-lipid-carrier-based-gel-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Blanka Sütö,1 Szilvia Berkó,1 Gábor Kozma,2 Ákos Kukovecz,2,3 Mária Budai-Szucs,1 Gábor Erös,4,5 Lajos Kemény,4 Anita Sztojkov-Ivanov,6 Róbert Gáspár,6 Erzsébet Csányi11Department of Pharmaceutical Technology, Faculty of Pharmacy, 2Department of Applied and Environmental Chemistry, 3MTA-SZTE “Lendület” Porous Nanocomposites Research Group, 4Department of Dermatology and Allergology, 5Department of Oral Biology and Experimental Dental Research, 6Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, HungaryAbstract: An ibuprofen-loaded nanostructured lipid carrier (IBU-NLC) was developed for enhanced skin penetration to improve the treatment of osteoarthritis and other musculoskeletal diseases. The mean particle size was 106 nm, with a spherical morphology, a smooth surface, and a zeta potential of −18.4 mV. X-ray diffraction studies revealed the amorphous state of the lipid matrix. Both Raman spectroscopy and Fourier transformation infrared analysis indicated no major shifts in the spectra of the formulations, which suggest rapid drug dissolution from the nanoparticles. The drug loading was 9.85%, and the entrapment efficiency was 98.51%. In vitro release of the NLC dispersion, in vitro permeation, and in vivo animal studies of IBU-NLC gel all confirmed that the permeation of IBU was significantly better than that of a reference after 6 hours. In conclusion, IBU-NLC gel is of great potential to enhance drug permeation through the skin and hence the efficacy of the treatment of chronic joint inflammation.Keywords: ibuprofen, nanostructured lipid carriers, skin penetration, SKH-1 hairless mice, osteoarthritisSütő BBerkó SKozma GKukovecz ÁBudai-Szűcs MErős GKemény LSztojkov-Ivanov AGáspár RCsányi EDove Medical PressarticleIbuprofenNanostructured lipid carriersSkin penetrationSKH-1 hairless miceOsteoarthritisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1201-1212 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ibuprofen Nanostructured lipid carriers Skin penetration SKH-1 hairless mice Osteoarthritis Medicine (General) R5-920
spellingShingle	Ibuprofen Nanostructured lipid carriers Skin penetration SKH-1 hairless mice Osteoarthritis Medicine (General) R5-920 Sütő B Berkó S Kozma G Kukovecz Á Budai-Szűcs M Erős G Kemény L Sztojkov-Ivanov A Gáspár R Csányi E Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
description	Blanka Sütö,1 Szilvia Berkó,1 Gábor Kozma,2 Ákos Kukovecz,2,3 Mária Budai-Szucs,1 Gábor Erös,4,5 Lajos Kemény,4 Anita Sztojkov-Ivanov,6 Róbert Gáspár,6 Erzsébet Csányi11Department of Pharmaceutical Technology, Faculty of Pharmacy, 2Department of Applied and Environmental Chemistry, 3MTA-SZTE “Lendület” Porous Nanocomposites Research Group, 4Department of Dermatology and Allergology, 5Department of Oral Biology and Experimental Dental Research, 6Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, HungaryAbstract: An ibuprofen-loaded nanostructured lipid carrier (IBU-NLC) was developed for enhanced skin penetration to improve the treatment of osteoarthritis and other musculoskeletal diseases. The mean particle size was 106 nm, with a spherical morphology, a smooth surface, and a zeta potential of −18.4 mV. X-ray diffraction studies revealed the amorphous state of the lipid matrix. Both Raman spectroscopy and Fourier transformation infrared analysis indicated no major shifts in the spectra of the formulations, which suggest rapid drug dissolution from the nanoparticles. The drug loading was 9.85%, and the entrapment efficiency was 98.51%. In vitro release of the NLC dispersion, in vitro permeation, and in vivo animal studies of IBU-NLC gel all confirmed that the permeation of IBU was significantly better than that of a reference after 6 hours. In conclusion, IBU-NLC gel is of great potential to enhance drug permeation through the skin and hence the efficacy of the treatment of chronic joint inflammation.Keywords: ibuprofen, nanostructured lipid carriers, skin penetration, SKH-1 hairless mice, osteoarthritis
format	article
author	Sütő B Berkó S Kozma G Kukovecz Á Budai-Szűcs M Erős G Kemény L Sztojkov-Ivanov A Gáspár R Csányi E
author_facet	Sütő B Berkó S Kozma G Kukovecz Á Budai-Szűcs M Erős G Kemény L Sztojkov-Ivanov A Gáspár R Csányi E
author_sort	Sütő B
title	Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
title_short	Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
title_full	Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
title_fullStr	Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
title_full_unstemmed	Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
title_sort	development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7ed3fc33b1c846099e7f4e0d12adc1f6
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Development of ibuprofen-loaded nanostructured lipid carrier-based gels: characterization and investigation of in vitro and in vivo penetration through the skin

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