Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women

Abstract Maternal HIV infection is associated with adverse pregnancy outcomes, but the mechanisms remain unknown. The course of pregnancy is regulated by immunological processes and HIV infection and antiretroviral therapy (ART) impact key immune mechanisms, which may disrupt the immune programme of...

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Autores principales:	Charlene Akoto, Shane A. Norris, Joris Hemelaar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ed4792097de46bfabd230bff571245a
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spelling	oai:doaj.org-article:7ed4792097de46bfabd230bff571245a2021-12-02T15:43:24ZMaternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women10.1038/s41598-021-89551-32045-2322https://doaj.org/article/7ed4792097de46bfabd230bff571245a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89551-3https://doaj.org/toc/2045-2322Abstract Maternal HIV infection is associated with adverse pregnancy outcomes, but the mechanisms remain unknown. The course of pregnancy is regulated by immunological processes and HIV infection and antiretroviral therapy (ART) impact key immune mechanisms, which may disrupt the immune programme of pregnancy. We evaluated a broad range of systemic cytokines at each trimester of pregnancy in 56 women living with HIV (WLHIV) and 68 HIV-negative women, who were enrolled in a prospective pregnancy cohort study in Soweto, South Africa. The pro-inflammatory cytokine IP-10 was detected in each trimester in all WLHIV, which was significantly more than in HIV-negative women. The anti-viral cytokine IFNλ1 was detected more frequently in WLHIV, whereas IFNβ and IFNλ2/3 were detected more frequently in HIV-negative women. Th1 cytokines IL-12 and IL-12p70, Th2 cytokine IL-5, and Th17 cytokine IL-17A were detected more frequently in WLHIV throughout pregnancy. Il-6, IL-9, and IL-10 were more commonly detected in WLHIV in the first trimester. Trends of increased detection of Th1 (IL-2, IL-12p70), Th2 (IL-4, Il-5, Il-13) and Th17 (IL-17A, Il-17F, IL-21, IL-22) cytokines were associated with small-for-gestational-age babies. Our findings indicate that maternal HIV/ART is associated with distinct systemic cytokine profiles throughout pregnancy.Charlene AkotoShane A. NorrisJoris HemelaarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Charlene Akoto Shane A. Norris Joris Hemelaar Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women
description	Abstract Maternal HIV infection is associated with adverse pregnancy outcomes, but the mechanisms remain unknown. The course of pregnancy is regulated by immunological processes and HIV infection and antiretroviral therapy (ART) impact key immune mechanisms, which may disrupt the immune programme of pregnancy. We evaluated a broad range of systemic cytokines at each trimester of pregnancy in 56 women living with HIV (WLHIV) and 68 HIV-negative women, who were enrolled in a prospective pregnancy cohort study in Soweto, South Africa. The pro-inflammatory cytokine IP-10 was detected in each trimester in all WLHIV, which was significantly more than in HIV-negative women. The anti-viral cytokine IFNλ1 was detected more frequently in WLHIV, whereas IFNβ and IFNλ2/3 were detected more frequently in HIV-negative women. Th1 cytokines IL-12 and IL-12p70, Th2 cytokine IL-5, and Th17 cytokine IL-17A were detected more frequently in WLHIV throughout pregnancy. Il-6, IL-9, and IL-10 were more commonly detected in WLHIV in the first trimester. Trends of increased detection of Th1 (IL-2, IL-12p70), Th2 (IL-4, Il-5, Il-13) and Th17 (IL-17A, Il-17F, IL-21, IL-22) cytokines were associated with small-for-gestational-age babies. Our findings indicate that maternal HIV/ART is associated with distinct systemic cytokine profiles throughout pregnancy.
format	article
author	Charlene Akoto Shane A. Norris Joris Hemelaar
author_facet	Charlene Akoto Shane A. Norris Joris Hemelaar
author_sort	Charlene Akoto
title	Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women
title_short	Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women
title_full	Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women
title_fullStr	Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women
title_full_unstemmed	Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women
title_sort	maternal hiv infection is associated with distinct systemic cytokine profiles throughout pregnancy in south african women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ed4792097de46bfabd230bff571245a
work_keys_str_mv	AT charleneakoto maternalhivinfectionisassociatedwithdistinctsystemiccytokineprofilesthroughoutpregnancyinsouthafricanwomen AT shaneanorris maternalhivinfectionisassociatedwithdistinctsystemiccytokineprofilesthroughoutpregnancyinsouthafricanwomen AT jorishemelaar maternalhivinfectionisassociatedwithdistinctsystemiccytokineprofilesthroughoutpregnancyinsouthafricanwomen
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Maternal HIV infection is associated with distinct systemic cytokine profiles throughout pregnancy in South African women

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