Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study

Type 2 diabetes might be influenced by colonic disease; however, the association between colonic resection and type 2 diabetes has rarely been discussed. This population-based cohort study explored the association between colectomy and type 2 diabetes in patients without colorectal cancer. A total o...

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Autores principales:	Chin-Chia Wu, Cheng-Hung Lee, Ta-Wen Hsu, Chia-Chou Yeh, Mei-Chen Lin, Chun-Ming Chang, Jui-Hsiu Tsai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	colectomy type 2 diabetes cohort study Medicine R
Acceso en línea:	https://doaj.org/article/7ed4e602e7ff48f584a377353b071338
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spelling	oai:doaj.org-article:7ed4e602e7ff48f584a377353b0713382021-11-25T18:01:42ZIs Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study10.3390/jcm102253132077-0383https://doaj.org/article/7ed4e602e7ff48f584a377353b0713382021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5313https://doaj.org/toc/2077-0383Type 2 diabetes might be influenced by colonic disease; however, the association between colonic resection and type 2 diabetes has rarely been discussed. This population-based cohort study explored the association between colectomy and type 2 diabetes in patients without colorectal cancer. A total of 642 patients who underwent colectomy for noncancerous diseases at any time between 2000 and 2012 in the National Health Insurance Research Database of Taiwan were enrolled. The enrolled patients were matched with 2568 patients without colectomy at a 1:4 ratio using a propensity score that covered age, sex, and comorbidities. The risk of type 2 diabetes was assessed using a Cox proportional hazards model. The mean (standard deviation) follow-up durations in colectomy cases and non-colectomy controls were 4.9 (4.0) and 5.6 (3.6) years, respectively; 65 (10.1%) colectomy cases and 342 (15.5%) non-colectomy controls developed type 2 diabetes. After adjustment, colectomy cases still exhibited a decreased risk of type 2 diabetes (adjusted HR = 0.80, 95% CI: 0.61–1.04). A stratified analysis for colectomy type indicated that patients who underwent right or transverse colectomy had a significantly lower risk of developing type 2 diabetes (adjusted HR = 0.57, 95% CI: 0.34–0.98). In the present study, colectomy tended to be at a reduced risk of type 2 diabetes in patients without colorectal cancer, and right or transverse colectomies were especially associated with a significantly reduced risk of type 2 diabetes.Chin-Chia WuCheng-Hung LeeTa-Wen HsuChia-Chou YehMei-Chen LinChun-Ming ChangJui-Hsiu TsaiMDPI AGarticlecolectomytype 2 diabetescohort studyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5313, p 5313 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colectomy type 2 diabetes cohort study Medicine R
spellingShingle	colectomy type 2 diabetes cohort study Medicine R Chin-Chia Wu Cheng-Hung Lee Ta-Wen Hsu Chia-Chou Yeh Mei-Chen Lin Chun-Ming Chang Jui-Hsiu Tsai Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
description	Type 2 diabetes might be influenced by colonic disease; however, the association between colonic resection and type 2 diabetes has rarely been discussed. This population-based cohort study explored the association between colectomy and type 2 diabetes in patients without colorectal cancer. A total of 642 patients who underwent colectomy for noncancerous diseases at any time between 2000 and 2012 in the National Health Insurance Research Database of Taiwan were enrolled. The enrolled patients were matched with 2568 patients without colectomy at a 1:4 ratio using a propensity score that covered age, sex, and comorbidities. The risk of type 2 diabetes was assessed using a Cox proportional hazards model. The mean (standard deviation) follow-up durations in colectomy cases and non-colectomy controls were 4.9 (4.0) and 5.6 (3.6) years, respectively; 65 (10.1%) colectomy cases and 342 (15.5%) non-colectomy controls developed type 2 diabetes. After adjustment, colectomy cases still exhibited a decreased risk of type 2 diabetes (adjusted HR = 0.80, 95% CI: 0.61–1.04). A stratified analysis for colectomy type indicated that patients who underwent right or transverse colectomy had a significantly lower risk of developing type 2 diabetes (adjusted HR = 0.57, 95% CI: 0.34–0.98). In the present study, colectomy tended to be at a reduced risk of type 2 diabetes in patients without colorectal cancer, and right or transverse colectomies were especially associated with a significantly reduced risk of type 2 diabetes.
format	article
author	Chin-Chia Wu Cheng-Hung Lee Ta-Wen Hsu Chia-Chou Yeh Mei-Chen Lin Chun-Ming Chang Jui-Hsiu Tsai
author_facet	Chin-Chia Wu Cheng-Hung Lee Ta-Wen Hsu Chia-Chou Yeh Mei-Chen Lin Chun-Ming Chang Jui-Hsiu Tsai
author_sort	Chin-Chia Wu
title	Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
title_short	Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
title_full	Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
title_fullStr	Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
title_full_unstemmed	Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
title_sort	is colectomy associated with the risk of type 2 diabetes in patients without colorectal cancer? a population-based cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ed4e602e7ff48f584a377353b071338
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Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study

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