The Role of NKL Homeobox Genes in T-Cell Malignancies

Homeobox genes encode transcription factors controlling basic developmental processes. The homeodomain is encoded by the homeobox and mediates sequence-specific DNA binding and interaction with cofactors, thus operating as a basic regulatory platform. Similarities in their homeobox sequences serve t...

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Autor principal:	Stefan Nagel
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	homeobox homeodomain NKL-code T-all lymphoma Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7ed51c4c460e471f91c5ffce01e51072
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id	oai:doaj.org-article:7ed51c4c460e471f91c5ffce01e51072
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spelling	oai:doaj.org-article:7ed51c4c460e471f91c5ffce01e510722021-11-25T16:50:39ZThe Role of NKL Homeobox Genes in T-Cell Malignancies10.3390/biomedicines91116762227-9059https://doaj.org/article/7ed51c4c460e471f91c5ffce01e510722021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1676https://doaj.org/toc/2227-9059Homeobox genes encode transcription factors controlling basic developmental processes. The homeodomain is encoded by the homeobox and mediates sequence-specific DNA binding and interaction with cofactors, thus operating as a basic regulatory platform. Similarities in their homeobox sequences serve to arrange these genes in classes and subclasses, including NKL homeobox genes. In accordance with their normal functions, deregulated homeobox genes contribute to carcinogenesis along with hematopoietic malignancies. We have recently described the physiological expression of eleven NKL homeobox genes in the course of hematopoiesis and termed this gene expression pattern NKL-code. Due to the developmental impact of NKL homeobox genes these data suggest a key role for their activity in the normal regulation of hematopoietic cell differentiation including T-cells. On the other hand, aberrant overexpression of NKL-code members or ectopical activation of non-code members has been frequently reported in lymphoid and myeloid leukemia/lymphoma, demonstrating their oncogenic impact in the hematopoietic compartment. Here, we provide an overview of the NKL-code in normal hematopoiesis and discuss the oncogenic role of deregulated NKL homeobox genes in T-cell malignancies.Stefan NagelMDPI AGarticlehomeoboxhomeodomainNKL-codeT-alllymphomaBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1676, p 1676 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	homeobox homeodomain NKL-code T-all lymphoma Biology (General) QH301-705.5
spellingShingle	homeobox homeodomain NKL-code T-all lymphoma Biology (General) QH301-705.5 Stefan Nagel The Role of NKL Homeobox Genes in T-Cell Malignancies
description	Homeobox genes encode transcription factors controlling basic developmental processes. The homeodomain is encoded by the homeobox and mediates sequence-specific DNA binding and interaction with cofactors, thus operating as a basic regulatory platform. Similarities in their homeobox sequences serve to arrange these genes in classes and subclasses, including NKL homeobox genes. In accordance with their normal functions, deregulated homeobox genes contribute to carcinogenesis along with hematopoietic malignancies. We have recently described the physiological expression of eleven NKL homeobox genes in the course of hematopoiesis and termed this gene expression pattern NKL-code. Due to the developmental impact of NKL homeobox genes these data suggest a key role for their activity in the normal regulation of hematopoietic cell differentiation including T-cells. On the other hand, aberrant overexpression of NKL-code members or ectopical activation of non-code members has been frequently reported in lymphoid and myeloid leukemia/lymphoma, demonstrating their oncogenic impact in the hematopoietic compartment. Here, we provide an overview of the NKL-code in normal hematopoiesis and discuss the oncogenic role of deregulated NKL homeobox genes in T-cell malignancies.
format	article
author	Stefan Nagel
author_facet	Stefan Nagel
author_sort	Stefan Nagel
title	The Role of NKL Homeobox Genes in T-Cell Malignancies
title_short	The Role of NKL Homeobox Genes in T-Cell Malignancies
title_full	The Role of NKL Homeobox Genes in T-Cell Malignancies
title_fullStr	The Role of NKL Homeobox Genes in T-Cell Malignancies
title_full_unstemmed	The Role of NKL Homeobox Genes in T-Cell Malignancies
title_sort	role of nkl homeobox genes in t-cell malignancies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ed51c4c460e471f91c5ffce01e51072
work_keys_str_mv	AT stefannagel theroleofnklhomeoboxgenesintcellmalignancies AT stefannagel roleofnklhomeoboxgenesintcellmalignancies
_version_	1718412905927409664

The Role of NKL Homeobox Genes in T-Cell Malignancies

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