Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis

Background: The relationship between urine output (UO) and in-hospital mortality in intensive care patients with septic shock is currently inconclusive.Methods: The baseline data, UO, and in-hospital prognosis of intensive care patients with septic shock were retrieved from the Medical Information M...

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Autores principales:	Tianyang Hu, Zhao Qiao, Ying Mei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	septic shock urine output MIMIC-IV in-hospital mortality propensity score matching Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7ed6383390cf4d99a36aae0c03a913fd
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spelling	oai:doaj.org-article:7ed6383390cf4d99a36aae0c03a913fd2021-11-18T07:32:40ZUrine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis2296-858X10.3389/fmed.2021.737654https://doaj.org/article/7ed6383390cf4d99a36aae0c03a913fd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.737654/fullhttps://doaj.org/toc/2296-858XBackground: The relationship between urine output (UO) and in-hospital mortality in intensive care patients with septic shock is currently inconclusive.Methods: The baseline data, UO, and in-hospital prognosis of intensive care patients with septic shock were retrieved from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. By drawing receiver operating characteristic (ROC) curves and comparing the areas under the ROC curves (AUC) to determine the predictive value of UO for in-hospital mortality, and by drawing the Kaplan-Meier curves to compare the difference in in-hospital mortality between different groups of UO.Results: Before and after the propensity score matching (PSM) analysis, UO was always a risk factor for in-hospital mortality in patients with septic shock. The AUC of UO was comparable to the Sequential Organ Failure Assessment (SOFA) scoring system, while the AUC of combining UO and SOFA was greater than that of SOFA. The median survival time of the high-UO group (UO > 0.39 ml/kg/h, before PSM; UO > 0.38 ml/kg/h, after PSM) was longer than that of the low-UO group. Compared with the high-UO group, the hazard ratios (HR) of the low-UO group were 2.6857 (before PSM) and 1.7879 (after PSM).Conclusions: UO is an independent risk factor for septic shock. Low levels of UO significantly increase the in-hospital mortality of intensive care patients with septic shock. The predictive value of UO is comparable to the SOFA scoring system, and the combined predictive value of the two surpasses SOFA alone.Tianyang HuZhao QiaoYing MeiFrontiers Media S.A.articleseptic shockurine outputMIMIC-IVin-hospital mortalitypropensity score matchingMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	septic shock urine output MIMIC-IV in-hospital mortality propensity score matching Medicine (General) R5-920
spellingShingle	septic shock urine output MIMIC-IV in-hospital mortality propensity score matching Medicine (General) R5-920 Tianyang Hu Zhao Qiao Ying Mei Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis
description	Background: The relationship between urine output (UO) and in-hospital mortality in intensive care patients with septic shock is currently inconclusive.Methods: The baseline data, UO, and in-hospital prognosis of intensive care patients with septic shock were retrieved from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. By drawing receiver operating characteristic (ROC) curves and comparing the areas under the ROC curves (AUC) to determine the predictive value of UO for in-hospital mortality, and by drawing the Kaplan-Meier curves to compare the difference in in-hospital mortality between different groups of UO.Results: Before and after the propensity score matching (PSM) analysis, UO was always a risk factor for in-hospital mortality in patients with septic shock. The AUC of UO was comparable to the Sequential Organ Failure Assessment (SOFA) scoring system, while the AUC of combining UO and SOFA was greater than that of SOFA. The median survival time of the high-UO group (UO > 0.39 ml/kg/h, before PSM; UO > 0.38 ml/kg/h, after PSM) was longer than that of the low-UO group. Compared with the high-UO group, the hazard ratios (HR) of the low-UO group were 2.6857 (before PSM) and 1.7879 (after PSM).Conclusions: UO is an independent risk factor for septic shock. Low levels of UO significantly increase the in-hospital mortality of intensive care patients with septic shock. The predictive value of UO is comparable to the SOFA scoring system, and the combined predictive value of the two surpasses SOFA alone.
format	article
author	Tianyang Hu Zhao Qiao Ying Mei
author_facet	Tianyang Hu Zhao Qiao Ying Mei
author_sort	Tianyang Hu
title	Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis
title_short	Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis
title_full	Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis
title_fullStr	Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis
title_full_unstemmed	Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis
title_sort	urine output is associated with in-hospital mortality in intensive care patients with septic shock: a propensity score matching analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7ed6383390cf4d99a36aae0c03a913fd
work_keys_str_mv	AT tianyanghu urineoutputisassociatedwithinhospitalmortalityinintensivecarepatientswithsepticshockapropensityscorematchinganalysis AT zhaoqiao urineoutputisassociatedwithinhospitalmortalityinintensivecarepatientswithsepticshockapropensityscorematchinganalysis AT yingmei urineoutputisassociatedwithinhospitalmortalityinintensivecarepatientswithsepticshockapropensityscorematchinganalysis
_version_	1718423296862584832

Urine Output Is Associated With In-hospital Mortality in Intensive Care Patients With Septic Shock: A Propensity Score Matching Analysis

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