Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations

Lister-Shimauchi et al. find that gametes from mutants that lack the genes encoding telomere binding proteins POT-1 or POT-2 affect the levels of POT1 telomere foci in progeny, in opposite ways, for multiple generations and that gametes deficient in heterochromatin formation reduce POT1 foci. These...

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Autores principales:	Evan H. Lister-Shimauchi, Michael Dinh, Paul Maddox, Shawn Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7ed77db08f1d42f8beaba614d871c636
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spelling	oai:doaj.org-article:7ed77db08f1d42f8beaba614d871c6362021-12-02T14:06:10ZGametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations10.1038/s42003-020-01624-72399-3642https://doaj.org/article/7ed77db08f1d42f8beaba614d871c6362021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01624-7https://doaj.org/toc/2399-3642Lister-Shimauchi et al. find that gametes from mutants that lack the genes encoding telomere binding proteins POT-1 or POT-2 affect the levels of POT1 telomere foci in progeny, in opposite ways, for multiple generations and that gametes deficient in heterochromatin formation reduce POT1 foci. These findings provide unexpected insights into an interface of telomere biology with transgenerational epigenetic inheritance.Evan H. Lister-ShimauchiMichael DinhPaul MaddoxShawn AhmedNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Evan H. Lister-Shimauchi Michael Dinh Paul Maddox Shawn Ahmed Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
description	Lister-Shimauchi et al. find that gametes from mutants that lack the genes encoding telomere binding proteins POT-1 or POT-2 affect the levels of POT1 telomere foci in progeny, in opposite ways, for multiple generations and that gametes deficient in heterochromatin formation reduce POT1 foci. These findings provide unexpected insights into an interface of telomere biology with transgenerational epigenetic inheritance.
format	article
author	Evan H. Lister-Shimauchi Michael Dinh Paul Maddox Shawn Ahmed
author_facet	Evan H. Lister-Shimauchi Michael Dinh Paul Maddox Shawn Ahmed
author_sort	Evan H. Lister-Shimauchi
title	Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
title_short	Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
title_full	Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
title_fullStr	Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
title_full_unstemmed	Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
title_sort	gametes deficient for pot1 telomere binding proteins alter levels of telomeric foci for multiple generations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ed77db08f1d42f8beaba614d871c636
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Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations

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