Current Potential Therapeutic Approaches against SARS-CoV-2: A Review

The ongoing SARS-CoV-2 pandemic is a serious threat to public health worldwide and, to date, no effective treatment is available. Thus, we herein review the pharmaceutical approaches to SARS-CoV-2 infection treatment. Numerous candidate medicines that can prevent SARS-CoV-2 infection and replication...

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Autores principales:	Dharmendra Kumar Yadav, Desh Deepak Singh, Ihn Han, Yogesh Kumar, Eun-Ha Choi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 combination therapy virus-based therapy host-based therapy SARS-CoV-2 cell entry inhibitors Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7edf80b3056749aeacc94deba4a2d3bd
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spelling	oai:doaj.org-article:7edf80b3056749aeacc94deba4a2d3bd2021-11-25T16:49:41ZCurrent Potential Therapeutic Approaches against SARS-CoV-2: A Review10.3390/biomedicines91116202227-9059https://doaj.org/article/7edf80b3056749aeacc94deba4a2d3bd2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1620https://doaj.org/toc/2227-9059The ongoing SARS-CoV-2 pandemic is a serious threat to public health worldwide and, to date, no effective treatment is available. Thus, we herein review the pharmaceutical approaches to SARS-CoV-2 infection treatment. Numerous candidate medicines that can prevent SARS-CoV-2 infection and replication have been proposed. These medicines include inhibitors of serine protease TMPRSS2 and angiotensin converting enzyme 2 (ACE2). The S protein of SARS-CoV-2 binds to the receptor in host cells. ACE2 inhibitors block TMPRSS2 and S protein priming, thus preventing SARS-CoV-2 entry to host cells. Moreover, antiviral medicines (including the nucleotide analogue remdesivir, the HIV protease inhibitors lopinavir and ritonavir, and wide-spectrum antiviral antibiotics arbidol and favipiravir) have been shown to reduce the dissemination of SARS-CoV-2 as well as morbidity and mortality associated with COVID-19.Dharmendra Kumar YadavDesh Deepak SinghIhn HanYogesh KumarEun-Ha ChoiMDPI AGarticleSARS-CoV-2combination therapyvirus-based therapyhost-based therapySARS-CoV-2 cell entry inhibitorsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1620, p 1620 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 combination therapy virus-based therapy host-based therapy SARS-CoV-2 cell entry inhibitors Biology (General) QH301-705.5
spellingShingle	SARS-CoV-2 combination therapy virus-based therapy host-based therapy SARS-CoV-2 cell entry inhibitors Biology (General) QH301-705.5 Dharmendra Kumar Yadav Desh Deepak Singh Ihn Han Yogesh Kumar Eun-Ha Choi Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
description	The ongoing SARS-CoV-2 pandemic is a serious threat to public health worldwide and, to date, no effective treatment is available. Thus, we herein review the pharmaceutical approaches to SARS-CoV-2 infection treatment. Numerous candidate medicines that can prevent SARS-CoV-2 infection and replication have been proposed. These medicines include inhibitors of serine protease TMPRSS2 and angiotensin converting enzyme 2 (ACE2). The S protein of SARS-CoV-2 binds to the receptor in host cells. ACE2 inhibitors block TMPRSS2 and S protein priming, thus preventing SARS-CoV-2 entry to host cells. Moreover, antiviral medicines (including the nucleotide analogue remdesivir, the HIV protease inhibitors lopinavir and ritonavir, and wide-spectrum antiviral antibiotics arbidol and favipiravir) have been shown to reduce the dissemination of SARS-CoV-2 as well as morbidity and mortality associated with COVID-19.
format	article
author	Dharmendra Kumar Yadav Desh Deepak Singh Ihn Han Yogesh Kumar Eun-Ha Choi
author_facet	Dharmendra Kumar Yadav Desh Deepak Singh Ihn Han Yogesh Kumar Eun-Ha Choi
author_sort	Dharmendra Kumar Yadav
title	Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
title_short	Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
title_full	Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
title_fullStr	Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
title_full_unstemmed	Current Potential Therapeutic Approaches against SARS-CoV-2: A Review
title_sort	current potential therapeutic approaches against sars-cov-2: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7edf80b3056749aeacc94deba4a2d3bd
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Current Potential Therapeutic Approaches against SARS-CoV-2: A Review

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