Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors show that incomplete ablation of tumours results in metastases and show in mouse models that the chemokine CCL2 recruits myeloid cells to the partially ablated tumours, which can block T cell function.

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Detalles Bibliográficos
Autores principales: Liangrong Shi, Junjun Wang, Nianhua Ding, Yi Zhang, Yibei Zhu, Shunli Dong, Xiaohui Wang, Changli Peng, Chunhui Zhou, Ledu Zhou, Xiaodong Li, Hongbing Shi, Wei Wu, Xueyin Long, Changping Wu, Weihua Liao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7ee06799e14541969149a6f48d4cd21b
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Descripción
Sumario:Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors show that incomplete ablation of tumours results in metastases and show in mouse models that the chemokine CCL2 recruits myeloid cells to the partially ablated tumours, which can block T cell function.