Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy
Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors show that incomplete ablation of tumours results in metastases and show in mouse models that the chemokine CCL2 recruits myeloid cells to the partially ablated tumours, which can block T cell function.
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Nature Portfolio
2019
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oai:doaj.org-article:7ee06799e14541969149a6f48d4cd21b2021-12-02T16:57:30ZInflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy10.1038/s41467-019-13204-32041-1723https://doaj.org/article/7ee06799e14541969149a6f48d4cd21b2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13204-3https://doaj.org/toc/2041-1723Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors show that incomplete ablation of tumours results in metastases and show in mouse models that the chemokine CCL2 recruits myeloid cells to the partially ablated tumours, which can block T cell function.Liangrong ShiJunjun WangNianhua DingYi ZhangYibei ZhuShunli DongXiaohui WangChangli PengChunhui ZhouLedu ZhouXiaodong LiHongbing ShiWei WuXueyin LongChangping WuWeihua LiaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Liangrong Shi Junjun Wang Nianhua Ding Yi Zhang Yibei Zhu Shunli Dong Xiaohui Wang Changli Peng Chunhui Zhou Ledu Zhou Xiaodong Li Hongbing Shi Wei Wu Xueyin Long Changping Wu Weihua Liao Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy |
| description |
Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors show that incomplete ablation of tumours results in metastases and show in mouse models that the chemokine CCL2 recruits myeloid cells to the partially ablated tumours, which can block T cell function. |
| format |
article |
| author |
Liangrong Shi Junjun Wang Nianhua Ding Yi Zhang Yibei Zhu Shunli Dong Xiaohui Wang Changli Peng Chunhui Zhou Ledu Zhou Xiaodong Li Hongbing Shi Wei Wu Xueyin Long Changping Wu Weihua Liao |
| author_facet |
Liangrong Shi Junjun Wang Nianhua Ding Yi Zhang Yibei Zhu Shunli Dong Xiaohui Wang Changli Peng Chunhui Zhou Ledu Zhou Xiaodong Li Hongbing Shi Wei Wu Xueyin Long Changping Wu Weihua Liao |
| author_sort |
Liangrong Shi |
| title |
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy |
| title_short |
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy |
| title_full |
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy |
| title_fullStr |
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy |
| title_full_unstemmed |
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy |
| title_sort |
inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders pd-1 immunotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7ee06799e14541969149a6f48d4cd21b |
| work_keys_str_mv |
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