An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy

Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon promotes polymerization of conductin/axin2, downregu...

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Autores principales:	Dominic B. Bernkopf, Martina Brückner, Michel V. Hadjihannas, Jürgen Behrens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ee0b10cbec64fbaa950ca92c1c59c9c
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spelling	oai:doaj.org-article:7ee0b10cbec64fbaa950ca92c1c59c9c2021-12-02T15:35:36ZAn aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy10.1038/s41467-019-12203-82041-1723https://doaj.org/article/7ee0b10cbec64fbaa950ca92c1c59c9c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12203-8https://doaj.org/toc/2041-1723Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon promotes polymerization of conductin/axin2, downregulation of Wnt pathway activity and growth inhibition of colorectal cancer cells.Dominic B. BernkopfMartina BrücknerMichel V. HadjihannasJürgen BehrensNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dominic B. Bernkopf Martina Brückner Michel V. Hadjihannas Jürgen Behrens An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
description	Polymerization of axin proteins is essential to suppress Wnt/β-catenin signaling. Here, the authors identify an aggregation site in the conductin/axin2 RGS domain that prevents its polymerization and show that a short peptide masking this aggregon promotes polymerization of conductin/axin2, downregulation of Wnt pathway activity and growth inhibition of colorectal cancer cells.
format	article
author	Dominic B. Bernkopf Martina Brückner Michel V. Hadjihannas Jürgen Behrens
author_facet	Dominic B. Bernkopf Martina Brückner Michel V. Hadjihannas Jürgen Behrens
author_sort	Dominic B. Bernkopf
title	An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
title_short	An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
title_full	An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
title_fullStr	An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
title_full_unstemmed	An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
title_sort	aggregon in conductin/axin2 regulates wnt/β-catenin signaling and holds potential for cancer therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7ee0b10cbec64fbaa950ca92c1c59c9c
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An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy

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