The COMET toolkit for composing customizable genetic programs in mammalian cells

Engineering mammalian cellular functions requires a toolkit of orthogonal and well-characterized genetic components. Here the authors develop COMET: an ensemble of transcription factors, promoters, and accompanying models for the design and construction of genetic programs.

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Autores principales:	Patrick S. Donahue, Joseph W. Draut, Joseph J. Muldoon, Hailey I. Edelstein, Neda Bagheri, Joshua N. Leonard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ee29a59a9554e1ba69e92cbf22088a7
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spelling	oai:doaj.org-article:7ee29a59a9554e1ba69e92cbf22088a72021-12-02T17:32:12ZThe COMET toolkit for composing customizable genetic programs in mammalian cells10.1038/s41467-019-14147-52041-1723https://doaj.org/article/7ee29a59a9554e1ba69e92cbf22088a72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14147-5https://doaj.org/toc/2041-1723Engineering mammalian cellular functions requires a toolkit of orthogonal and well-characterized genetic components. Here the authors develop COMET: an ensemble of transcription factors, promoters, and accompanying models for the design and construction of genetic programs.Patrick S. DonahueJoseph W. DrautJoseph J. MuldoonHailey I. EdelsteinNeda BagheriJoshua N. LeonardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patrick S. Donahue Joseph W. Draut Joseph J. Muldoon Hailey I. Edelstein Neda Bagheri Joshua N. Leonard The COMET toolkit for composing customizable genetic programs in mammalian cells
description	Engineering mammalian cellular functions requires a toolkit of orthogonal and well-characterized genetic components. Here the authors develop COMET: an ensemble of transcription factors, promoters, and accompanying models for the design and construction of genetic programs.
format	article
author	Patrick S. Donahue Joseph W. Draut Joseph J. Muldoon Hailey I. Edelstein Neda Bagheri Joshua N. Leonard
author_facet	Patrick S. Donahue Joseph W. Draut Joseph J. Muldoon Hailey I. Edelstein Neda Bagheri Joshua N. Leonard
author_sort	Patrick S. Donahue
title	The COMET toolkit for composing customizable genetic programs in mammalian cells
title_short	The COMET toolkit for composing customizable genetic programs in mammalian cells
title_full	The COMET toolkit for composing customizable genetic programs in mammalian cells
title_fullStr	The COMET toolkit for composing customizable genetic programs in mammalian cells
title_full_unstemmed	The COMET toolkit for composing customizable genetic programs in mammalian cells
title_sort	comet toolkit for composing customizable genetic programs in mammalian cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7ee29a59a9554e1ba69e92cbf22088a7
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The COMET toolkit for composing customizable genetic programs in mammalian cells

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