ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Abstract Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evid...

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Main Authors:	Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, Marju Orho-Melander, Olle Melander, Jan Nilsson, Anna Hultgårdh-Nilsson, Isabel Gonçalves
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/7ee6747cf6c04da9988e3b3a763f33a5
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spelling	oai:doaj.org-article:7ee6747cf6c04da9988e3b3a763f33a52021-12-02T12:32:28ZADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis10.1038/s41598-017-03573-42045-2322https://doaj.org/article/7ee6747cf6c04da9988e3b3a763f33a52017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03573-4https://doaj.org/toc/2045-2322Abstract Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated. Carotid plaques (n = 206) from patients with and without cerebrovascular symptoms were analyzed for expression of ADAMTS-7 by immunohistochemistry and correlated to components associated with plaque vulnerability. Plaques from symptomatic patients showed increased levels of ADAMTS-7 compared with lesions from asymptomatic patients. High levels of ADAMTS-7 correlated with high levels of CD68-staining and lipid content, but with low smooth muscle cell and collagen content, which together are characteristics of a vulnerable plaque phenotype. ADAMTS-7 levels above median were associated with increased risk for postoperative cardiovascular events. Our data show that ADAMTS-7 is associated with a vulnerable plaque phenotype in human carotid lesions. These data support previous observations of a potential proatherogenic role of ADAMTS-7.Eva BengtssonKarin HultmanPontus DunérGiuseppe AsciuttoPeter AlmgrenMarju Orho-MelanderOlle MelanderJan NilssonAnna Hultgårdh-NilssonIsabel GonçalvesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eva Bengtsson Karin Hultman Pontus Dunér Giuseppe Asciutto Peter Almgren Marju Orho-Melander Olle Melander Jan Nilsson Anna Hultgårdh-Nilsson Isabel Gonçalves ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
description	Abstract Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated. Carotid plaques (n = 206) from patients with and without cerebrovascular symptoms were analyzed for expression of ADAMTS-7 by immunohistochemistry and correlated to components associated with plaque vulnerability. Plaques from symptomatic patients showed increased levels of ADAMTS-7 compared with lesions from asymptomatic patients. High levels of ADAMTS-7 correlated with high levels of CD68-staining and lipid content, but with low smooth muscle cell and collagen content, which together are characteristics of a vulnerable plaque phenotype. ADAMTS-7 levels above median were associated with increased risk for postoperative cardiovascular events. Our data show that ADAMTS-7 is associated with a vulnerable plaque phenotype in human carotid lesions. These data support previous observations of a potential proatherogenic role of ADAMTS-7.
format	article
author	Eva Bengtsson Karin Hultman Pontus Dunér Giuseppe Asciutto Peter Almgren Marju Orho-Melander Olle Melander Jan Nilsson Anna Hultgårdh-Nilsson Isabel Gonçalves
author_facet	Eva Bengtsson Karin Hultman Pontus Dunér Giuseppe Asciutto Peter Almgren Marju Orho-Melander Olle Melander Jan Nilsson Anna Hultgårdh-Nilsson Isabel Gonçalves
author_sort	Eva Bengtsson
title	ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
title_short	ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
title_full	ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
title_fullStr	ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
title_full_unstemmed	ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis
title_sort	adamts-7 is associated with a high-risk plaque phenotype in human atherosclerosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7ee6747cf6c04da9988e3b3a763f33a5
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ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

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