Transcriptional repression shapes the identity and function of tissue macrophages

The changing extra‐ and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells respond and adapt to different environmental stimuli. I...

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Autores principales:	Krisztian Bene, Laszlo Halasz, Laszlo Nagy
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	epigenome genome macrophage repression tissue‐resident transcription Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/7ee836fa369845efb2919cba586eecec
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spelling	oai:doaj.org-article:7ee836fa369845efb2919cba586eecec2021-12-01T13:36:12ZTranscriptional repression shapes the identity and function of tissue macrophages2211-546310.1002/2211-5463.13269https://doaj.org/article/7ee836fa369845efb2919cba586eecec2021-12-01T00:00:00Zhttps://doi.org/10.1002/2211-5463.13269https://doaj.org/toc/2211-5463The changing extra‐ and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells respond and adapt to different environmental stimuli. Innate immune cells such as macrophages are able to modulate their transcriptional programs and epigenetic regulatory networks through activation and repression of particular genes, allowing them to quickly respond to a rapidly changing environment. Tissue macrophages are essential components of different immune‐ and nonimmune cell‐mediated physiological mechanisms in mammals and are widely used models for investigating transcriptional regulatory mechanisms. Therefore, it is critical to unravel the distinct sets of transcription activators, repressors, and coregulators that play roles in determining tissue macrophage identity and functions during homeostasis, as well as in diseases affecting large human populations, such as metabolic syndromes, immune‐deficiencies, and tumor development. In this review, we will focus on transcriptional repressors that play roles in tissue macrophage development and function under physiological conditions.Krisztian BeneLaszlo HalaszLaszlo NagyWileyarticleepigenomegenomemacrophagerepressiontissue‐residenttranscriptionBiology (General)QH301-705.5ENFEBS Open Bio, Vol 11, Iss 12, Pp 3218-3229 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epigenome genome macrophage repression tissue‐resident transcription Biology (General) QH301-705.5
spellingShingle	epigenome genome macrophage repression tissue‐resident transcription Biology (General) QH301-705.5 Krisztian Bene Laszlo Halasz Laszlo Nagy Transcriptional repression shapes the identity and function of tissue macrophages
description	The changing extra‐ and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells respond and adapt to different environmental stimuli. Innate immune cells such as macrophages are able to modulate their transcriptional programs and epigenetic regulatory networks through activation and repression of particular genes, allowing them to quickly respond to a rapidly changing environment. Tissue macrophages are essential components of different immune‐ and nonimmune cell‐mediated physiological mechanisms in mammals and are widely used models for investigating transcriptional regulatory mechanisms. Therefore, it is critical to unravel the distinct sets of transcription activators, repressors, and coregulators that play roles in determining tissue macrophage identity and functions during homeostasis, as well as in diseases affecting large human populations, such as metabolic syndromes, immune‐deficiencies, and tumor development. In this review, we will focus on transcriptional repressors that play roles in tissue macrophage development and function under physiological conditions.
format	article
author	Krisztian Bene Laszlo Halasz Laszlo Nagy
author_facet	Krisztian Bene Laszlo Halasz Laszlo Nagy
author_sort	Krisztian Bene
title	Transcriptional repression shapes the identity and function of tissue macrophages
title_short	Transcriptional repression shapes the identity and function of tissue macrophages
title_full	Transcriptional repression shapes the identity and function of tissue macrophages
title_fullStr	Transcriptional repression shapes the identity and function of tissue macrophages
title_full_unstemmed	Transcriptional repression shapes the identity and function of tissue macrophages
title_sort	transcriptional repression shapes the identity and function of tissue macrophages
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/7ee836fa369845efb2919cba586eecec
work_keys_str_mv	AT krisztianbene transcriptionalrepressionshapestheidentityandfunctionoftissuemacrophages AT laszlohalasz transcriptionalrepressionshapestheidentityandfunctionoftissuemacrophages AT laszlonagy transcriptionalrepressionshapestheidentityandfunctionoftissuemacrophages
_version_	1718405126438256640

Transcriptional repression shapes the identity and function of tissue macrophages

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