Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Glaucoma is a neurodegenerative disease of which the etiology is still unclear. Here the authors show that elevation of intraocular pressure induces T cell infiltration in the eyes. Furthermore, they show that T cell cross-reactivity between endogenous and commensal antigens contributes to disease o...

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Autores principales:	Huihui Chen, Kin-Sang Cho, T. H. Khanh Vu, Ching-Hung Shen, Mandeep Kaur, Guochun Chen, Rose Mathew, M. Lisa McHam, Ahad Fazelat, Kameran Lashkari, Ngan Pan Bennett Au, Joyce Ka Yu Tse, Yingqian Li, Honghua Yu, Lanbo Yang, Joan Stein-Streilein, Chi Him Eddie Ma, Clifford J. Woolf, Mark T. Whary, Martine J. Jager, James G. Fox, Jianzhu Chen, Dong F. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7eeb4b55f6d24b608f92e5fd00d35529
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spelling	oai:doaj.org-article:7eeb4b55f6d24b608f92e5fd00d355292021-12-02T15:34:44ZCommensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma10.1038/s41467-018-05681-92041-1723https://doaj.org/article/7eeb4b55f6d24b608f92e5fd00d355292018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05681-9https://doaj.org/toc/2041-1723Glaucoma is a neurodegenerative disease of which the etiology is still unclear. Here the authors show that elevation of intraocular pressure induces T cell infiltration in the eyes. Furthermore, they show that T cell cross-reactivity between endogenous and commensal antigens contributes to disease onset in mice.Huihui ChenKin-Sang ChoT. H. Khanh VuChing-Hung ShenMandeep KaurGuochun ChenRose MathewM. Lisa McHamAhad FazelatKameran LashkariNgan Pan Bennett AuJoyce Ka Yu TseYingqian LiHonghua YuLanbo YangJoan Stein-StreileinChi Him Eddie MaClifford J. WoolfMark T. WharyMartine J. JagerJames G. FoxJianzhu ChenDong F. ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huihui Chen Kin-Sang Cho T. H. Khanh Vu Ching-Hung Shen Mandeep Kaur Guochun Chen Rose Mathew M. Lisa McHam Ahad Fazelat Kameran Lashkari Ngan Pan Bennett Au Joyce Ka Yu Tse Yingqian Li Honghua Yu Lanbo Yang Joan Stein-Streilein Chi Him Eddie Ma Clifford J. Woolf Mark T. Whary Martine J. Jager James G. Fox Jianzhu Chen Dong F. Chen Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
description	Glaucoma is a neurodegenerative disease of which the etiology is still unclear. Here the authors show that elevation of intraocular pressure induces T cell infiltration in the eyes. Furthermore, they show that T cell cross-reactivity between endogenous and commensal antigens contributes to disease onset in mice.
format	article
author	Huihui Chen Kin-Sang Cho T. H. Khanh Vu Ching-Hung Shen Mandeep Kaur Guochun Chen Rose Mathew M. Lisa McHam Ahad Fazelat Kameran Lashkari Ngan Pan Bennett Au Joyce Ka Yu Tse Yingqian Li Honghua Yu Lanbo Yang Joan Stein-Streilein Chi Him Eddie Ma Clifford J. Woolf Mark T. Whary Martine J. Jager James G. Fox Jianzhu Chen Dong F. Chen
author_facet	Huihui Chen Kin-Sang Cho T. H. Khanh Vu Ching-Hung Shen Mandeep Kaur Guochun Chen Rose Mathew M. Lisa McHam Ahad Fazelat Kameran Lashkari Ngan Pan Bennett Au Joyce Ka Yu Tse Yingqian Li Honghua Yu Lanbo Yang Joan Stein-Streilein Chi Him Eddie Ma Clifford J. Woolf Mark T. Whary Martine J. Jager James G. Fox Jianzhu Chen Dong F. Chen
author_sort	Huihui Chen
title	Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
title_short	Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
title_full	Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
title_fullStr	Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
title_full_unstemmed	Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma
title_sort	commensal microflora-induced t cell responses mediate progressive neurodegeneration in glaucoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7eeb4b55f6d24b608f92e5fd00d35529
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Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

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